El Safoury Omar Soliman, Fawzy Marwa M, El Maadawa Zeinab M, Mohamed Dalia H
Department of Dermatology, Faculty of Medicine, Cairo University, Egypt.
Indian J Dermatol. 2009;54(4):319-22. doi: 10.4103/0019-5154.57605.
Skin tags are common benign skin tumors usually occurring on the neck and major flexors of elder people.
The aim of this study is to perform quantitation of mast cells and collagen fibers in skin tags and normal skin in diabetics and nondiabetics, to find a possible correlation between mast cells and collagen fibers in the pathogenesis of skin tags.
Thirty participants with skin tags were divided into two groups (15 diabetic and 15 nondiabetic). Three biopsies were obtained from one anatomical site: A large skin tag, a small skin tag, and adjacent normal skin. Mast cells stained with Bismarck brown were counted manually in ten different fields of each section with magnification x1000 and the average count was correlated with the percentage of mean collagen area in five fields done by the image analyzer.
A statistically significant correlation between mast cell count and percentage of collagen mean area was detected in both studied groups (except in large skin tags of the nondiabetic group).
The positive correlation between mast cell count and percentage of collagen mean area suggests the critical role of mast cells in the etiogenesis of skin tags through its interaction with fibroblasts.
皮赘是常见的良性皮肤肿瘤，通常发生在老年人的颈部和主要屈侧部位。
本研究旨在对糖尿病患者和非糖尿病患者的皮赘及正常皮肤中的肥大细胞和胶原纤维进行定量分析，以探寻肥大细胞与胶原纤维在皮赘发病机制中可能存在的相关性。
30名患有皮赘的参与者被分为两组（15名糖尿病患者和15名非糖尿病患者）。从一个解剖部位获取三块活检组织：一个大的皮赘、一个小的皮赘以及相邻的正常皮肤。用俾斯麦棕染色的肥大细胞在每个切片的十个不同视野中以1000倍放大倍数进行手动计数，平均计数与图像分析仪在五个视野中测得的平均胶原面积百分比相关。
在两个研究组中均检测到肥大细胞计数与胶原平均面积百分比之间存在统计学显著相关性（非糖尿病组的大皮赘除外）。
肥大细胞计数与胶原平均面积百分比之间的正相关表明肥大细胞通过与成纤维细胞相互作用在皮赘病因形成中起关键作用。
