Dianzani C, Calvieri S, Pierangeli A, Imperi M, Bucci M, Degener A M
Institute of Dermatological Clinic, La Sapienza University of Rome, Italy.
Br J Dermatol. 1998 Apr;138(4):649-51. doi: 10.1046/j.1365-2133.1998.02178.x.
Human papillomavirus (HPV) is associated with benign cutaneous or mucosal lesions and with malignant tumours, but none of the HPV types has so far been related to skin tags. Skin biopsy specimens from 49 Caucasian patients suffering from the presence of multiple soft fibromas were analysed by means of dot blot hybridization and by polymerase chain reaction assays aimed at detecting all known HPV types. The results revealed the presence of HPV DNA type 6/11 in 88% of the skin tags examined. This result supports the hypothesis that HPV plays a part in the progression of cutaneous soft fibromas, as previously reported for laryngeal papillomas.
人乳头瘤病毒（HPV）与良性皮肤或粘膜病变以及恶性肿瘤有关，但迄今为止，尚无任何一种HPV类型与皮赘相关。通过斑点杂交和旨在检测所有已知HPV类型的聚合酶链反应分析，对49例患有多发性软纤维瘤的白种人患者的皮肤活检标本进行了分析。结果显示，在88%的检测皮赘中存在6/11型HPV DNA。这一结果支持了HPV在皮肤软纤维瘤进展中起作用的假说，正如先前关于喉乳头状瘤的报道。
