Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec City, Canada.
Can J Cardiol. 2010 Jan;26(1):17-21. doi: 10.1016/s0828-282x(10)70328-7.
The natural history of intermittent claudication, from its risk factors to its cardiovascular prognosis, has been reported in few prospective studies.
To assess incident intermittent claudication, as well as its risk factors and long-term prognosis in men.
A random sample of 4376 men 35 to 64 years of age from Quebec City (Quebec), who were free of cardiovascular disease (CVD), was evaluated in 1974 for CVD risk factors and followed until 1998. To assess the prognosis, the event rates between 1985 and 1998 were computed among men with incident claudication without other CVD, incident survivors of a first myocardial infarction (MI) without other CVD and men free of CVD between 1974 and 1985.
From 1974 to 1998, 300 men developed intermittent claudication. Tobacco consumption, high systolic blood pressure and diabetes at least doubled the adjusted RR (aRR) of intermittent claudication. In 1985, there were 80 claudicants, 2868 men free of CVD and 68 survivors of a first MI. During the 13-year follow-up, a new CVD occurred in 48.8% of the claudicants, in 18.9% of men without CVD (aRR 2.08; 95% CI 1.48 to 2.90) and in 45.6% of MI survivors (aRR compared with claudicants 1.12; 95% CI 0.69 to 1.79). There was also no significant difference between claudicants and MI survivors for fatal CVD, nonfatal CVD and total mortality.
Men with intermittent claudication are at high risk for CVD that may be equivalent to men with previous MI.
间歇性跛行的自然病史，从其危险因素到心血管预后，在为数不多的前瞻性研究中有过报道。
评估男性中偶发性间歇性跛行及其危险因素和长期预后。
1974 年，对来自魁北克市（魁北克省）的 4376 名年龄在 35 至 64 岁之间、无心血管疾病（CVD）的男性进行了一项随机抽样，评估了 CVD 危险因素，并随访至 1998 年。为了评估预后，计算了 1985 年至 1998 年期间无其他 CVD 的偶发性跛行男性、无其他 CVD 的首次心肌梗死（MI）幸存者和 1974 年至 1985 年期间无 CVD 的男性之间的事件发生率。
1974 年至 1998 年期间，有 300 名男性发生间歇性跛行。吸烟、高收缩压和糖尿病使间歇性跛行的调整后的相对风险（aRR）增加了一倍以上。1985 年，有 80 名跛行患者、2868 名无 CVD 的男性和 68 名首次 MI 的幸存者。在 13 年的随访期间，48.8%的跛行患者发生了新的 CVD，18.9%的无 CVD 男性（aRR 2.08；95%CI 1.48 至 2.90）和 45.6%的 MI 幸存者（与跛行患者相比，aRR 为 1.12；95%CI 0.69 至 1.79）。跛行患者与 MI 幸存者之间在致命性 CVD、非致命性 CVD 和总死亡率方面也没有显著差异。
患有间歇性跛行的男性发生 CVD 的风险很高，这可能与以前患有 MI 的男性相当。
