Schorn C, Behr C, Schwarting A
Zentrales Röntgeninstitut des Sana Rheumazentrums Rheinland-Pfalz.
Dtsch Med Wochenschr. 2010 Jan;135(4):125-8. doi: 10.1055/s-0029-1244828. Epub 2010 Jan 25.
A 67-years-old man suffered from relapsing moderate fever and back pain after arthroscopy of the knee under peridural anaesthesia. Antibiotics given for suspected iatrogenic infection was started, but was without improvement. After 4 months under several antibiotic regimes his condition rapidly deteriorated with high fever, excruciating lumbar back pain associated with elevated ESR/WBC (ESR = erythrocyte sedimentation rate, WBC = white blood cell count) along with arthritis of the shoulders, wrists, knees and ankles. Physical findings comprised swelling and restricted movement of the affected joints as well as pain related stiffness and immobility of the spine, but no neurological abnormalities.
An magnetic resonance imaging (MRI) of the lumbar spine revealed the uncommon finding of multilevel facet joint arthritis at lumbar L2/3 and L4/5, accompanied by cystic erosions of the lamina and widespread dorsal soft tissue edema. Serum uric acid was 11 mg/dl. Uric acid was found in the synovial fluid of the knees.
DIAGNOSIS, TREATMENT AND FOLLOW UP: The fever, spinal symptoms as well as imaging findings improved together with the peripheral arthritis when treatment with colchicine and steroids was started, establishing the diagnosis of spinal gout. In the following year, no further or back pain or fever occurred. Despite continued allopurinol therapy the gouty arthritis of the peripheral joints re-occurred.
Despite its rarity, spinal gout should be considered in the differential diagnosis of intractable back pain and fever especially when imaging studies reveal posterior element involvement.
一名67岁男性在硬膜外麻醉下进行膝关节关节镜检查后,反复出现中度发热和背痛。因怀疑医源性感染开始使用抗生素,但病情无改善。在接受几种抗生素治疗4个月后,他的病情迅速恶化,出现高热、剧烈腰背痛,血沉(ESR)/白细胞(WBC)升高(ESR =红细胞沉降率,WBC =白细胞计数),同时伴有肩部、腕部、膝部和踝部关节炎。体格检查发现受累关节肿胀、活动受限,脊柱疼痛相关僵硬及活动障碍,但无神经功能异常。
腰椎磁共振成像(MRI)显示L2/3和L4/5节段罕见的多节段小关节关节炎,伴有椎板囊性侵蚀和广泛的背部软组织水肿。血清尿酸为11mg/dl。膝关节滑液中发现尿酸。
诊断、治疗与随访:开始使用秋水仙碱和类固醇治疗后,发热、脊柱症状以及影像学表现与外周关节炎一同改善,确诊为脊柱痛风。在接下来的一年里,未再出现背痛或发热。尽管继续使用别嘌醇治疗,外周关节痛风性关节炎仍复发。
尽管脊柱痛风罕见,但在鉴别诊断顽固性背痛和发热时应考虑到,尤其是影像学检查显示后部结构受累时。