Institute for Lasers, Photonics and Biophotonics, SUNY at Buffalo, Buffalo, NY, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 Mar-Apr;2(2):162-75. doi: 10.1002/wnan.67.
This review presents recent progress in the development of the luminescent nanoparticles for confocal and multiphoton microscopy. Four classes of nanomaterials are discussed: (1) silica-based nanoparticles doped with fluorescent molecules, (2) gold nanoparticles, (3) semiconductor nanocrystals (quantum dots/rods), and (4) nanophosphors. Special considerations are given to recently developed imaging nanoprobes, such as (1) organically modified silica (ORMOSIL) nanoparticles doped with two-photon absorbing fluorophores, which exhibit aggregation-enhanced fluorescence (AEF), and (2) nanophosphors (ceramic nanoparticles containing luminescent lanthanoid ions). Advantages and disadvantages of every class of nanomaterials and their specific applications are briefly discussed.
这篇综述介绍了用于共聚焦和多光子显微镜的荧光纳米粒子的最新进展。讨论了四类纳米材料：（1）掺杂荧光分子的硅基纳米粒子，（2）金纳米粒子，（3）半导体纳米晶体（量子点/棒），和（4）纳米荧光粉。特别考虑了最近开发的成像纳米探针，例如（1）用双光子吸收荧光团掺杂的有机改性硅（ORMOSIL）纳米粒子，其表现出聚集增强荧光（AEF），和（2）纳米荧光粉（含有发光镧系离子的陶瓷纳米粒子）。简要讨论了每类纳米材料的优缺点及其特定应用。
