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The genetic basis of negative selection of Tcrb-V11+ T cells.

作者信息

Tomonari K, Fairchild S

机构信息

Transplantation Biology Section, MRC Clinical Research Centre, Middlesex, England.

出版信息

Immunogenetics. 1991;33(3):157-62. doi: 10.1007/BF01719234.

DOI:10.1007/BF01719234
PMID:2010217
Abstract

Non-H-2 genes responsible for negative selection of Tcrb-V11+ T cells were examined using backcross mice of various strains with C58, which does not delete Tcrb-V11+ T cells. Two independently segregating genes were found: one leading to partial deletion was closely linked to Ly-2/Ly-3 on chromosome 6, and the second giving virtually complete deletion has not yet been mapped. The A strain had only the former, whereas BALB/c, BALB.K, B10.BR, CBA-T6, C3H/He, and DBA/2 expressed both of these genes. Although a gene(s) of the NIH strain led only to partial deletion, the chromosomal localization of the gene(s) has not yet been determined: no informative polymorphic molecules are expressed from genes on chromosome 6 of this strain.

摘要

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引用本文的文献

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Co-segregation of a gene encoding a deletion ligand for Tcrb-V3+ T cells with Mtv-3.

本文引用的文献

1
IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.与携带Lyt 2抗原的分子复合物上不同决定簇发生反应的IgG或IgM单克隆抗体，在无补体情况下可阻断T细胞介导的细胞溶解作用。
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T cell tolerance by clonal elimination in the thymus.胸腺中通过克隆清除实现的T细胞耐受性。
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The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens.
Immunogenetics. 1991;34(4):227-30. doi: 10.1007/BF00215257.
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Negative selection of Tcra-V8+CD8+ T cells by MHC class I molecules.
Immunogenetics. 1992;35(5):291-5. doi: 10.1007/BF00189891.
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Immunogenetics of human minor histocompatibility antigens: their polymorphism and immunodominance.
Immunogenetics. 1992;35(3):161-5. doi: 10.1007/BF00185109.
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Influence of T cell receptor V alpha expression on Mlsa superantigen-specific T cell responses.T细胞受体Vα表达对Mlsa超抗原特异性T细胞应答的影响。
J Exp Med. 1992 May 1;175(5):1405-8. doi: 10.1084/jem.175.5.1405.
7
Positive selection of Tcrb-V10b+ T cells.
Immunogenetics. 1992;35(1):9-15. doi: 10.1007/BF00216621.
8
Tcrb-V3+ T-cell deletion and a mouse mammary tumor provirus, Mtv-27.Tcrb-V3+ T细胞缺失与一种小鼠乳腺肿瘤前病毒Mtv-27
Immunogenetics. 1992;36(5):302-5. doi: 10.1007/BF00215658.
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Positive and negative selection of Tcrb-V6+ T cells.
Immunogenetics. 1992;36(4):230-7. doi: 10.1007/BF00215053.
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Tcrb-V3+ T-cell deletion and a new mouse mammary tumor provirus, Mtv-44.Tcrb-V3+ T细胞缺失与一种新的小鼠乳腺肿瘤前病毒，Mtv-44。
Immunogenetics. 1992;36(3):189-94. doi: 10.1007/BF00661096.
T细胞库受到对多态性自身抗原耐受性的严重影响。
Nature. 1988 Oct 27;335(6193):796-801. doi: 10.1038/335796a0.
4
Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression.Ly-3和Ly-2基因的分子连锁。Ly-2对Ly-3表面表达的需求。
J Immunol. 1988 May 15;140(10):3646-53.
5
T cells can distinguish between allogeneic major histocompatibility complex products on different cell types.T细胞能够区分不同细胞类型上的同种异体主要组织相容性复合体产物。
Nature. 1988 Apr 28;332(6167):840-3. doi: 10.1038/332840a0.
6
T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens.T细胞受体Vβ的使用可预测对Mlsa编码抗原的反应性和耐受性。
Nature. 1988 Mar 3;332(6159):40-5. doi: 10.1038/332040a0.
7
Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex.自身耐受性会清除针对主要组织相容性复合体的Mls修饰产物具有特异性的T细胞。
Nature. 1988 Mar 3;332(6159):35-40. doi: 10.1038/332035a0.
8
The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.主要组织相容性复合体（MHC）分子I-E对于携带Vβ11的T细胞的克隆清除是必要的，但并不充分。
J Exp Med. 1989 Apr 1;169(4):1405-19. doi: 10.1084/jem.169.4.1405.
9
Capacity of unprimed CD4+ and CD8+ T cells expressing V beta 11 receptors to respond to I-E alloantigens in vivo.表达Vβ11受体的未致敏CD4+和CD8+ T细胞在体内对I-E同种异体抗原作出反应的能力。
J Exp Med. 1989 Dec 1;170(6):1947-57. doi: 10.1084/jem.170.6.1947.
10
A third T-cell receptor beta-chain variable region gene encodes reactivity to Mls-1a gene products.第三个T细胞受体β链可变区基因编码对Mls-1a基因产物的反应性。
Proc Natl Acad Sci U S A. 1989 Aug;86(16):6293-6. doi: 10.1073/pnas.86.16.6293.