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Co-segregation of a gene encoding a deletion ligand for Tcrb-V3+ T cells with Mtv-3.

作者信息

Fairchild S, Knight A M, Dyson P J, Tomonari K

机构信息

Transplantation Biology Section, MRC Clinical Research Centre, Harrow, Middlesex, England.

出版信息

Immunogenetics. 1991;34(4):227-30. doi: 10.1007/BF00215257.

DOI:10.1007/BF00215257
PMID:1655644
Abstract

A gene encoding the endogenous superantigen Mlsc, which deletes Tcrb-V3+ T cells in the NOD inbred mouse strain, was found to co-segregate with Mtv-3 on chromosome 11. This identifies a fourth gene encoding a deletion ligand for Tcrb-V3+ T cells and extends recently published observations in support of the hypothesis that a number of endogenous superantigens are the products of Mtv proviruses.

摘要

相似文献

1
Co-segregation of a gene encoding a deletion ligand for Tcrb-V3+ T cells with Mtv-3.
Immunogenetics. 1991;34(4):227-30. doi: 10.1007/BF00215257.
2
Tcrb-V3+ T-cell deletion and a new mouse mammary tumor provirus, Mtv-44.Tcrb-V3+ T细胞缺失与一种新的小鼠乳腺肿瘤前病毒，Mtv-44。
Immunogenetics. 1992;36(3):189-94. doi: 10.1007/BF00661096.
3
Tcrb-V3+ T-cell deletion and a mouse mammary tumor provirus, Mtv-27.Tcrb-V3+ T细胞缺失与一种小鼠乳腺肿瘤前病毒Mtv-27
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4
Thymic repertoire selection by superantigens: presentation by human and mouse MHC molecules.超抗原对胸腺库的选择：人源和鼠源MHC分子的呈递
Thymus. 1994;23(1):1-13.
5
Tissue distribution of Mtv-7-like exogenous retroviral transcripts and clonal deletion of V beta 6+ T cells in Mls-1b BALB/c mice.Mls-1b BALB/c小鼠中Mtv-7样外源性逆转录病毒转录本的组织分布及Vβ6 + T细胞的克隆缺失
Int Immunol. 1993 Feb;5(2):217-22. doi: 10.1093/intimm/5.2.217.
6
Mls-1-like superantigen in the MA/MyJ mouse is encoded by a new mammary tumor provirus that is distinct from Mtv-7.MA/MyJ小鼠中的Mls-1样超抗原由一种新的乳腺肿瘤前病毒编码，该病毒与Mtv-7不同。
J Exp Med. 1992 Jun 1;175(6):1613-21. doi: 10.1084/jem.175.6.1613.
7
Delay in expression of a mammary tumor provirus is responsible for defective clonal deletion during postnatal period.乳腺肿瘤前病毒表达的延迟是出生后时期克隆清除缺陷的原因。
Eur J Immunol. 1994 Feb;24(2):488-91. doi: 10.1002/eji.1830240235.
8
A new gene encoding the ligand for deletion of T cells bearing Tcrb-V6 and V8.1 (Mtv-50).
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9
Mouse endogenous superantigens: Ms and Mls-like determinants encoded by mouse retroviruses.
Curr Protoc Immunol. 2001 May;Appendix 1:Appendix 1F. doi: 10.1002/0471142735.ima01fs17.
10
Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice.Mls基因与近交系小鼠内源性乳腺肿瘤病毒的连锁关系。
Nature. 1991 Feb 7;349(6309):526-8. doi: 10.1038/349526a0.

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Deletion of Vβ3CD4 T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8 T cells.内源性小鼠乳腺肿瘤病毒 3 缺失 Vβ3CD4 T 细胞可预防自身反应性 CD8 T 细胞诱导的 1 型糖尿病。
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本文引用的文献

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Immunogenetic and biological aspects of in vitro lymphocyte allotransformation (MLR) in the mouse.小鼠体外淋巴细胞同种异体转化（混合淋巴细胞反应）的免疫遗传学和生物学方面
Transplant Rev. 1973;15:62-88. doi: 10.1111/j.1600-065x.1973.tb00111.x.
2
T cell tolerance by clonal elimination in the thymus.胸腺中通过克隆清除实现的T细胞耐受性。
Cell. 1987 Apr 24;49(2):273-80. doi: 10.1016/0092-8674(87)90568-x.
3
A T cell receptor V beta segment that imparts reactivity to a class II major histocompatibility complex product.一种赋予对II类主要组织相容性复合体产物反应性的T细胞受体Vβ区段。
Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10 mouse model of inflammatory bowel disease.
鼠乳腺瘤病毒与 IL-10 小鼠模型中结肠炎的严重程度和菌群失调有关。
Microbiome. 2023 Mar 3;11(1):39. doi: 10.1186/s40168-023-01483-4.
4
Representational difference analysis in a lupus-prone mouse strain results in the identification of an unstable region of the genome on chromosome 11.对一种狼疮易发性小鼠品系进行代表性差异分析，结果在11号染色体上鉴定出基因组的一个不稳定区域。
Nucleic Acids Res. 2002 Mar 15;30(6):1394-400. doi: 10.1093/nar/30.6.1394.
5
Transcription originating in the long terminal repeats of the endogenous mouse mammary tumor virus MTV-3 is activated in Stat5a-null mice and picks Up hitchhiking exons.起源于内源性小鼠乳腺肿瘤病毒MTV-3长末端重复序列的转录在Stat5a基因敲除小鼠中被激活，并携带了一些附带的外显子。
J Virol. 1999 Oct;73(10):8669-76. doi: 10.1128/JVI.73.10.8669-8676.1999.
6
Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease.自身抗原谷氨酸脱羧酶65（GAD65）转基因的广泛表达不能使非肥胖型糖尿病小鼠产生免疫耐受，反而会加剧疾病。
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10055-60. doi: 10.1073/pnas.95.17.10055.
7
A comparative study of T-cell receptor V beta usage in non-obese diabetic (NOD) and I-E transgenic NOD mice.非肥胖糖尿病（NOD）小鼠和I-E转基因NOD小鼠中T细胞受体Vβ使用情况的比较研究。
Immunology. 1993 Apr;78(4):606-10.
8
Bacterial and viral superantigens: roles in autoimmunity?细菌和病毒超抗原：在自身免疫中的作用？
Ann Rheum Dis. 1993 Mar;52 Suppl 1(Suppl 1):S6-16. doi: 10.1136/ard.52.suppl_1.s6.
9
Characterization of experimental allergic encephalomyelitis-susceptible, Biozzi AB/H (H-2dq1) mice which express H-2Anod: analysis of T-cell receptor expression and the detection of a deletion ligand encoded by Mtv-7.表达H-2Anod的实验性变应性脑脊髓炎易感Biozzi AB/H（H-2dq1）小鼠的特征：T细胞受体表达分析及Mtv-7编码的缺失配体的检测
Immunology. 1993 Feb;78(2):260-5.
10
T-cell receptor b-V repertoire expression in the absence of an endogenous mouse mammary tumor provirus.内源性小鼠乳腺肿瘤前病毒缺失时T细胞受体b-V谱系的表达
Immunogenetics. 1993;37(4):309-11. doi: 10.1007/BF00187461.
Cell. 1987 Apr 24;49(2):263-71. doi: 10.1016/0092-8674(87)90567-8.
4
The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens.T细胞库受到对多态性自身抗原耐受性的严重影响。
Nature. 1988 Oct 27;335(6193):796-801. doi: 10.1038/335796a0.
5
T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens.T细胞受体Vβ的使用可预测对Mlsa编码抗原的反应性和耐受性。
Nature. 1988 Mar 3;332(6159):40-5. doi: 10.1038/332040a0.
6
Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex.自身耐受性会清除针对主要组织相容性复合体的Mls修饰产物具有特异性的T细胞。
Nature. 1988 Mar 3;332(6159):35-40. doi: 10.1038/332035a0.
7
A standardized nomenclature for endogenous mouse mammary tumor viruses.内源性小鼠乳腺肿瘤病毒的标准化命名法。
J Virol. 1987 May;61(5):1651-4. doi: 10.1128/JVI.61.5.1651-1654.1987.
8
Characterization, chromosome assignment, and segregation analysis of endogenous proviral units of mouse mammary tumor virus.小鼠乳腺肿瘤病毒内源性前病毒单位的特性鉴定、染色体定位及分离分析
J Virol. 1986 Sep;59(3):535-44. doi: 10.1128/JVI.59.3.535-544.1986.
9
Preferential expression of the T-cell receptor V beta 3 gene by Mlsc reactive T cells.Mlsc反应性T细胞对T细胞受体Vβ3基因的优先表达。
Nature. 1988 Oct 27;335(6193):827-30. doi: 10.1038/335827a0.
10
The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.主要组织相容性复合体（MHC）分子I-E对于携带Vβ11的T细胞的克隆清除是必要的，但并不充分。
J Exp Med. 1989 Apr 1;169(4):1405-19. doi: 10.1084/jem.169.4.1405.