Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
J Am Chem Soc. 2010 Feb 17;132(6):1784-5. doi: 10.1021/ja910278e.
Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T(1) decay of magnetization. Due to its long T(1), the hyperpolarized (89)Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the (89)Y chemical shift dependence upon pH for two hyperpolarized (89)Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH.
极化可以提高 NMR/MRI 实验的灵敏度，但主要的限制是磁化强度的 T(1)衰减。由于其较长的 T(1)，超极化的 (89)Y 核是作为体内光谱/成像探针的理想候选物。本文报道了两种超极化 (89)Y(III) 配合物的 (89)Y 化学位移随 pH 的变化，并证明了这些配合物如何可作为灵敏的光谱/成像试剂来测量 pH。
