高极化 89Y 配合物作为 pH 敏感的 NMR 探针。
Hyperpolarized 89Y complexes as pH sensitive NMR probes.
机构信息
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
出版信息
J Am Chem Soc. 2010 Feb 17;132(6):1784-5. doi: 10.1021/ja910278e.
Abstract
Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T(1) decay of magnetization. Due to its long T(1), the hyperpolarized (89)Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the (89)Y chemical shift dependence upon pH for two hyperpolarized (89)Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH.
摘要
极化可以提高 NMR/MRI 实验的灵敏度，但主要的限制是磁化强度的 T(1)衰减。由于其较长的 T(1)，超极化的 (89)Y 核是作为体内光谱/成像探针的理想候选物。本文报道了两种超极化 (89)Y(III) 配合物的 (89)Y 化学位移随 pH 的变化，并证明了这些配合物如何可作为灵敏的光谱/成像试剂来测量 pH。
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