Division of Analytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA.
J Agric Food Chem. 2010 Feb 24;58(4):2307-13. doi: 10.1021/jf903959u.
An updated survey of U.S. infant formula was conducted to determine the concentrations of bisphenol A (BPA). The purpose was to accurately assess BPA concentrations across the infant formula market, accounting for lot variability, and determine if geographic location or can age influences BPA concentrations. A method was developed to measure BPA in formula utilizing isotope dilution, solid-phase extraction, and liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The method was tested and found to be reproducible (10% relative standard deviation), reliable (47 +/- 1% recovery), and sensitive (0.15 ng g(-1) method detection limit). Over 160 analyses were conducted using 104 formula containers representing 36 products. Samples from U.S. east and west coast markets demonstrated no significant difference, and concentrations in older cans were not higher. BPA concentrations in liquid formula (0.48-11 ng g(-1)) were consistent with previous studies, and BPA was detected in only 1 of 14 powder formula products analyzed.
对美国婴儿配方奶粉进行了更新的调查，以确定双酚 A (BPA) 的浓度。目的是准确评估婴儿配方奶粉市场的 BPA 浓度，考虑到批次变化，并确定地理位置或罐头年龄是否会影响 BPA 浓度。开发了一种利用同位素稀释、固相萃取和液相色谱-串联质谱 (HPLC-MS/MS) 测量配方中 BPA 的方法。该方法经过测试，结果表明具有可重复性（10%相对标准偏差）、可靠性（47 +/- 1%回收率）和灵敏度（0.15ng g(-1)方法检测限）。使用代表 36 种产品的 104 个配方容器进行了超过 160 次分析。来自美国东海岸和西海岸市场的样本没有明显差异，旧罐中的浓度也没有更高。液体配方中的 BPA 浓度（0.48-11ng g(-1)）与之前的研究一致，在分析的 14 种粉状配方产品中仅检测到 1 种含有 BPA。
