Electrophysiology Unit, Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy.
Am Heart J. 2010 Jan;159(1):98-102. doi: 10.1016/j.ahj.2009.10.031.
The assessment of defibrillation efficacy using a safety margin of 10 J has long been the standard of care for insertion of implantable cardioverter-defibrillator (ICD), but physicians are concerned about complications related to induction test. Therefore, the need for testing has been recently questioned. The aim of our study was to assess the impact of defibrillation threshold (DFT) testing of ICD on the efficacy of ICD therapy.
We analyzed data obtained from follow-up visits of 122 consecutive patients who underwent ICD implantation at our institute from April 1996 to June 2008, with (n = 42) or without (n = 80) DFT testing. Patients in the DFT group were less likely to be men (83.3% vs 96.3%, P < .031) than those in the non-DFT group. Conversely, the 2 groups were similar in age, left ventricular ejection fraction at baseline, functional class, and underlying cardiovascular disease. Results during a 12-month follow-up, 13 (31.0%) and 30 (37.5%) ventricular tachyarrhythmic episodes were recorded in the DFT and non-DFT groups, respectively (P = .472). Antitachycardia pacing (ATP) terminated most of episodes, reducing the need of defibrillation at 7.7% in the DFT group and 3.3% in the non-DFT group (P = .533). Similar percentages of inappropriate ATP interventions (7.1% vs 3.8%, P = .413) and shock deliveries (2.4% vs 5.0%, P = .659) were recorded between DFT and non-DFT groups.
At 1-year follow-up, the performance of DFT testing does not seem to add any significant efficacy advantage in patients undergoing ICD implantation. Prospective randomized trials and long-term follow-up are warranted to clarify whether routine DFT testing may be safely abandoned leading to a revision of current guidelines.
使用 10J 的安全裕度评估除颤效果一直是植入式心脏复律除颤器(ICD)插入的标准护理,但医生担心与诱导测试相关的并发症。因此,最近对测试的需求提出了质疑。我们的研究目的是评估 ICD 除颤阈值(DFT)测试对 ICD 治疗效果的影响。
我们分析了 1996 年 4 月至 2008 年 6 月在我们研究所接受 ICD 植入的 122 例连续患者的随访数据,其中(n=42)或未进行(n=80)DFT 测试。DFT 组的男性患者比例明显低于非 DFT 组(83.3%比 96.3%,P<0.031)。相反,两组在年龄、基线左心室射血分数、功能分级和基础心血管疾病方面相似。在 12 个月的随访期间,DFT 组和非 DFT 组分别记录了 13(31.0%)和 30(37.5%)次室性心动过速事件(P=0.472)。抗心动过速起搏(ATP)终止了大多数发作,DFT 组的除颤需求降低至 7.7%,而非 DFT 组的需求降低至 3.3%(P=0.533)。DFT 组和非 DFT 组分别记录到相似百分比的不适当 ATP 干预(7.1%比 3.8%,P=0.413)和电击(2.4%比 5.0%,P=0.659)。
在 1 年的随访中,DFT 测试的性能似乎不能为接受 ICD 植入的患者带来任何显著的疗效优势。需要前瞻性随机试验和长期随访来阐明是否可以安全地放弃常规 DFT 测试,从而修订当前的指南。