Delporte M P, Benayoun R, Willer J C, Thomas M
Sem Hop. 1977;53(34-35):1835-42.
A study of 30 cases of Grave's disease confirmed the frequency of hyperthyroid myopathy, whether obvious or revealed by E.M.G. More than by the association of various symptoms (pretibial myxoedema, antithyroid antibodies), we were struck by the multiple symptoms of Grave's disease with myopathy, which confirms the anglo-saxon concept of the polysystemic nature of Grave's disease. This symptomatic richness is not necessarily proportional to the thyroid hypersecretion, and one may suppose that these patients have a greater peripheral sensitivity to the effects of hormone excess, which would explain the multiple clinical signs. The frequency of neuropathy seemed to us more important than usually believed. The clinical signs are often, or absent, or may be masked by the predominance of muscle wasting. If E.M.G. of the distal muscle and measurement of conduction rates were carried out more often as a routine, this would no doubt permit better assessment of the true frequency of neural involvement.
一项对30例格雷夫斯病患者的研究证实了甲状腺功能亢进性肌病的发生率，无论其是否明显或通过肌电图显示。与其说是各种症状（胫前黏液性水肿、抗甲状腺抗体）的关联，不如说是格雷夫斯病合并肌病的多种症状给我们留下了深刻印象，这证实了盎格鲁-撒克逊人关于格雷夫斯病多系统性质的概念。这种症状的丰富性不一定与甲状腺分泌过多成正比，人们可能会认为这些患者对激素过量的影响具有更高的外周敏感性，这可以解释多种临床体征。在我们看来，神经病变的发生率比通常认为的更为重要。临床体征常常不存在，或者可能被肌肉萎缩的优势所掩盖。如果更经常地将远端肌肉的肌电图检查和传导速度测量作为常规操作，无疑将有助于更好地评估神经受累的真实发生率。
