Le Marec H, Probst V
Département de Cardiologie, Hôpitaux de Brabois, Allée du Morvan, 54511 Vandoeuvre lès Nancy, France.
Ann Cardiol Angeiol (Paris). 2009 Dec;58 Suppl 1:S70-2. doi: 10.1016/S0003-3928(09)73407-9.
Atrial fibrillation is the most common cardiac arrhythmia. The identification of familial forms of atrial fibrillation as well as epidemiological studies have confirmed the presence of a genetic background. Familial forms are rare diseases, and the common form is a multifactorial and probably multigenic disease largely modulated by environmental factors. New research developments, based on GWAS studies of well define large cohorts, should, in the near future, help to better characterize the different genetic profiles of this disease, the first step for the identification of new therapeutic targets.
心房颤动是最常见的心律失常。家族性心房颤动的鉴定以及流行病学研究已经证实了其遗传背景的存在。家族性形式是罕见疾病，而常见形式是一种多因素且可能是多基因的疾病，很大程度上受环境因素调节。基于对明确界定的大型队列进行全基因组关联研究的新研究进展，在不久的将来应该有助于更好地表征这种疾病的不同基因谱，这是识别新治疗靶点的第一步。
