Arizona Cancer Center and Department of Cell Biology and Anatomy, The University of Arizona, Tucson, USA.
Cancer Prev Res (Phila). 2010 Feb;3(2):125-7. doi: 10.1158/1940-6207.CAPR-09-0252. Epub 2010 Jan 26.
Ornithine decarboxylase has a relatively long history as a target for cancer chemoprevention and chemotherapy. Plym Forshell et al. report new evidence (beginning on p. 140 in this issue of the journal) indicating that spermidine synthase, a fellow enzyme of ornithine decarboxylase in polyamine metabolism, is transactivated in part by the MYC gene and is a potential target for chemoprevention of B-cell lymphomas.
鸟氨酸脱羧酶作为癌症化学预防和化疗的靶点具有相当长的历史。Plym Forshell 等人报告了新的证据(详见本期杂志第 140 页),表明多胺代谢中的鸟氨酸脱羧酶的同工酶——精脒合成酶部分受 MYC 基因的反式激活,是预防 B 细胞淋巴瘤的潜在靶点。