Suzuki Kotaro, Yamashita Yuzo, Matuzaki Junichi
The Department of Urology, Ohguchi Higashi General Hospital.
Hinyokika Kiyo. 2010 Jan;56(1):5-9.
We investigated the patients with ammonium acid urate (AAU) calculi in relation to dietary history, habit and lifestyle. From April, 2002 to March, 2009, AAU calculi were found in 9 patients (0.66) out of 1,365 cases of stones. Three cases were pure, and 6 were mixed stones. We examined the risk factor of this stone generation, "continuation of malnutrition and dehydration" were seen in 5, "continuing urinary tract infection" was seen in 4 and "continuation of super-saturation of uric acid in urine" was seen in 3 cases. All the patients with "continuation of malnutrition and dehydration" were women, and 4 patients had a history of severe body weight loss. 2 patients were dieting consciously, and the other 2 were eating a poorly balanced diet unconsciously. One patient had no notable past history, but malnutrition was detected in blood examination. It is suggested that AAU calculi is generated even by dieting at a usual level. Compared with the report in the United States, obesity and inflammatory bowel disease were not major risk factors, and "continuation of malnutrition and dehydration" is the major factor in Japan.
我们针对尿酸铵（AAU）结石患者，调查了其饮食史、习惯及生活方式。2002年4月至2009年3月期间，在1365例结石病例中，发现9例（0.66%）为尿酸铵结石。其中3例为单纯结石，6例为混合结石。我们研究了这种结石形成的危险因素，5例存在“营养不良和脱水持续”情况，4例存在“持续性尿路感染”，3例存在“尿液中尿酸持续过饱和”。所有存在“营养不良和脱水持续”情况的患者均为女性，4例患者有严重体重减轻史。2例患者有意识地节食，另外2例无意识地饮食不均衡。1例患者无明显既往史，但血液检查发现营养不良。这表明即使是正常程度的节食也可能导致尿酸铵结石的形成。与美国的报告相比，肥胖和炎症性肠病并非主要危险因素，而在日本“营养不良和脱水持续”是主要因素。
