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先天代谢差异。

Inborn variation in metabolism.

出版信息

Nat Genet. 2010 Feb;42(2):97-8. doi: 10.1038/ng0210-97.

DOI:10.1038/ng0210-97
PMID:20104246
Abstract

Advances in analytical biochemistry have recently made it possible to obtain global snapshots of metabolism. A new study couples such technology with genome-wide genetic analysis to explore inherited variation in human metabolism.

摘要

分析生物化学的最新进展使得获取代谢的全局快照成为可能。一项新的研究将这种技术与全基因组遗传分析相结合，以探索人类代谢中的遗传变异。

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Metabolomic epidemiology offers insights into disease aetiology.代谢组学流行病学为疾病病因学提供了新的见解。
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本文引用的文献

1
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.新的遗传位点与空腹血糖稳态有关，及其对 2 型糖尿病风险的影响。
Nat Genet. 2010 Feb;42(2):105-16. doi: 10.1038/ng.520. Epub 2010 Jan 17.
2
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.GIPR 基因变异影响口服葡萄糖耐量试验中血糖和胰岛素的反应。
Nat Genet. 2010 Feb;42(2):142-8. doi: 10.1038/ng.521. Epub 2010 Jan 17.
3
A genome-wide perspective of genetic variation in human metabolism.
临床生物样本库中基于基因型的“虚拟”代谢组学鉴定出新的代谢物-疾病关联。
Res Sq. 2023 Oct 11:rs.3.rs-3222588. doi: 10.21203/rs.3.rs-3222588/v2.
4
Emerging Insights into the Metabolic Alterations in Aging Using Metabolomics.利用代谢组学对衰老过程中代谢变化的新见解
Metabolites. 2019 Dec 13;9(12):301. doi: 10.3390/metabo9120301.
5
Dynamic modelling of an ACADS genotype in fatty acid oxidation - Application of cellular models for the analysis of common genetic variants.ACADS 基因型在脂肪酸氧化中的动态建模——细胞模型在常见遗传变异分析中的应用。
PLoS One. 2019 May 23;14(5):e0216110. doi: 10.1371/journal.pone.0216110. eCollection 2019.
6
An atlas of genetic influences on human blood metabolites.人类血液代谢物遗传影响图谱。
Nat Genet. 2014 Jun;46(6):543-550. doi: 10.1038/ng.2982. Epub 2014 May 11.
7
13C-isotope-based protocol for prenyl lipid metabolic analysis in zebrafish embryos.基于 13C 同位素的斑马鱼胚胎类异戊二烯脂质代谢分析方案。
Nat Protoc. 2013 Dec;8(12):2337-47. doi: 10.1038/nprot.2013.139. Epub 2013 Oct 31.
8
Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits.表观遗传学与代谢组学的交汇：一项针对血清代谢特征的全基因组关联研究。
Hum Mol Genet. 2014 Jan 15;23(2):534-45. doi: 10.1093/hmg/ddt430. Epub 2013 Sep 6.
9
Omics technologies and the study of human ageing.组学技术与人类衰老研究。
Nat Rev Genet. 2013 Sep;14(9):601-7. doi: 10.1038/nrg3553. Epub 2013 Aug 13.
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Predicting the impact of diet and enzymopathies on human small intestinal epithelial cells.预测饮食和酶病对人类小肠上皮细胞的影响。
Hum Mol Genet. 2013 Jul 1;22(13):2705-22. doi: 10.1093/hmg/ddt119. Epub 2013 Mar 13.
人类代谢中遗传变异的全基因组视角。
Nat Genet. 2010 Feb;42(2):137-41. doi: 10.1038/ng.507. Epub 2009 Dec 27.
4
Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study.基安蒂研究中血浆多不饱和脂肪酸的全基因组关联研究。
PLoS Genet. 2009 Jan;5(1):e1000338. doi: 10.1371/journal.pgen.1000338. Epub 2009 Jan 16.
5
Common variants at 30 loci contribute to polygenic dyslipidemia.30个基因座上的常见变异导致多基因血脂异常。
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6
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.遗传学与代谢组学相遇：人类血清代谢物谱的全基因组关联研究。
PLoS Genet. 2008 Nov;4(11):e1000282. doi: 10.1371/journal.pgen.1000282. Epub 2008 Nov 28.
7
Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.代谢和心血管特征：大量最近发现的常见基因变异体。
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The genetics of plant metabolism.植物代谢遗传学
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