伴有精神病性特征的大麻所致双相情感障碍：一例报告
Cannabis-induced bipolar disorder with psychotic features: a case report.
作者信息
Khan Masood A, Akella Sailaja
机构信息
Staff Psychiatrist at the Greater Binghamton Health Center, Binghamton, New York; fourth year student, New York College of Osteopathic Medicine, New York, New York.
出版信息
Psychiatry (Edgmont). 2009 Dec;6(12):44-8.
Abstract
There has been considerable debate regarding the causal relationship between chronic cannabis abuse and psychiatric disorders. Clinicians agree that cannabis use can cause acute adverse mental effects that mimic psychiatric disorders, such as schizophrenia and bipolar disorder. Although there is good evidence to support this, the connections are complex and not fully understood.As the research in the endocannabinoid system is emerging, the neurobiological effects of cannabis are being evaluated in the development of psychiatric illness for those individuals who may be genetically vulnerable. Here we present a case of a college student who initially suffered from an acute psychotic breakdown secondary to cannabis abuse that manifested into bipolar disorder with psychosis.
摘要
关于慢性大麻滥用与精神疾病之间的因果关系，一直存在着相当多的争论。临床医生一致认为，使用大麻会导致类似精神疾病（如精神分裂症和双相情感障碍）的急性不良精神效应。尽管有充分的证据支持这一点，但两者之间的联系很复杂，尚未完全被理解。随着内源性大麻素系统研究的不断涌现，对于那些可能具有遗传易感性的个体，大麻的神经生物学效应正在精神疾病的发展过程中得到评估。在此，我们呈现一个大学生的案例，该学生最初因大麻滥用继发急性精神病性发作，后发展为伴有精神病性症状的双相情感障碍。
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