两种对映异构体的 C(2)对称 Ti(IV) 酚氧络合物的显著不同细胞毒性；对机理的启示。
Markedly different cytotoxicity of the two enantiomers of C(2)-symmetrical Ti(IV) phenolato complexes; mechanistic implications.
机构信息
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
出版信息
Dalton Trans. 2010 Feb 7;39(5):1182-4. doi: 10.1039/b920786b. Epub 2009 Nov 2.
DOI:10.1039/b920786b
PMID:20104339
Abstract
The two enantiomers of a member of the highly active C(2)-symmetrical bis(isopropoxo) Ti(iv) family of complexes of diamine bis(phenolato) ligands demonstrate markedly different cytotoxicity, supporting a chiral biological target of activity and participation of a ligand-bound active species.
摘要
手性双（苯氧）二胺配体的高活性 C(2)-对称双异丙氧基 Ti(iv) 配合物家族中的一员的两个对映异构体表现出明显不同的细胞毒性，支持活性的手性生物靶标和配体结合的活性物种的参与。
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