Zeitzer Jamie M, Friedman Leah, O'Hara Ruth
VA Palo Alto Health Care System, 3801 Miranda Avenue (151Y), Palo Alto, CA 94304, USA.
J Rehabil Res Dev. 2009;46(6):827-36. doi: 10.1682/jrrd.2008.08.0099.
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality in the United States. One of the most common comorbidities of TBI is the disruption of normal sleep. While often viewed as a nuisance symptom, sleep disruption can delay TBI recovery and negatively affect many of the psychological (e.g., anxiety, depression) and neuromuscular (e.g., pain) sequelae of TBI, decreasing quality of life. Treatment of sleep disruption in the context of TBI is complicated by issues of an altered neuronal milieu, polypharmacy, and the complex relationship between the various comorbidities often found in patients with TBI. Given the growing number of veterans returning from combat with TBI and the elevated risk of comorbid disrupted sleep, both caused by and independent of TBI, a comprehensive review of sleep disruption and its treatment is of great relevance to the Department of Veterans Affairs.
创伤性脑损伤（TBI）是美国发病和死亡的主要原因之一。TBI最常见的合并症之一是正常睡眠的中断。虽然睡眠中断通常被视为一种令人讨厌的症状，但它会延迟TBI的恢复，并对TBI的许多心理（如焦虑、抑郁）和神经肌肉（如疼痛）后遗症产生负面影响，降低生活质量。TBI背景下睡眠中断的治疗因神经元环境改变、多种药物治疗以及TBI患者中常见的各种合并症之间的复杂关系而变得复杂。鉴于从战斗中归来的患有TBI的退伍军人数量不断增加，以及由TBI引起或与TBI无关的合并性睡眠中断风险升高，对睡眠中断及其治疗进行全面综述对退伍军人事务部具有重要意义。
