Keenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.
Faculty of Medicine, Division of Geriatric Psychiatry, Department of Psychiatry, University of Toronto, Toronto, Canada.
Int Rev Psychiatry. 2020 Feb;32(1):39-45. doi: 10.1080/09540261.2019.1657384. Epub 2019 Sep 23.
Older adults are particularly vulnerable to poor long-term outcomes, and the rate of TBI in this group is increasing. Studies have shown females experience worse outcomes from TBI than males, however this research has been limited. The aim of this study is to examine gender effects on the frequency of sleep disturbances in older adults post-TBI. An analysis was conducted on data obtained from the National Alzheimer's Coordinating Center (NACC) Uniform Data Set. A total of 405 patients greater than 60 years of age were examined. Sleep disturbances were measured using the Nighttime Behavioural Disturbances domain of the Neuropsychiatric Inventory-Questionnaire (NPI-Q). A significant difference ( = 0.025) in reported sleep disturbance was identified in the female TBI population relative to the female non-TBI population. In the male non-TBI group, 14.8% ( = 12) experienced nighttime disturbances while 19.8% ( = 17) of those with TBI experienced nighttime disturbances. This difference was not significant ( = 0.305). These results suggest there is a greater impact from traumatic brain injury on sleep disturbances in older females than males. Further research examining gender differences in older adults related to neuropsychiatric outcomes of TBI should be considered given the implications for treatment.
老年人尤其容易受到长期预后不良的影响,而且该人群中创伤性脑损伤的发生率正在增加。研究表明,女性在创伤性脑损伤后比男性的预后更差,但这项研究受到了限制。本研究旨在探讨性别对创伤性脑损伤后老年人睡眠障碍频率的影响。对来自国家阿尔茨海默病协调中心(NACC)统一数据集的数据进行了分析。共检查了 405 名年龄大于 60 岁的患者。使用神经精神疾病问卷-问卷(NPI-Q)的夜间行为障碍域来测量睡眠障碍。与女性非创伤性脑损伤组相比,女性创伤性脑损伤组报告的睡眠障碍存在显著差异( = 0.025)。在男性非创伤性脑损伤组中,14.8%( = 12)的患者出现夜间障碍,而 19.8%( = 17)的创伤性脑损伤患者出现夜间障碍。这一差异无统计学意义( = 0.305)。这些结果表明,创伤性脑损伤对老年女性睡眠障碍的影响大于男性。鉴于治疗的影响,应考虑进一步研究创伤性脑损伤对老年患者神经精神结局的性别差异。