Reza Fatemi, Amir Mohammad Alizadeh, Faramarz Derakhshan, Shahrokh Mousavi, Mehrdad Zahmatkesh, Shivarani Sepideh, Malek Fateme Nemati, Maserat Elham, Zali M R
Research Center of Gastroenterology and Liver Disease, Semnan University of Medical Sciences, Fatemieh Hospital, Tehran, Iran.
Asian Pac J Cancer Prev. 2009;10(5):739-41.
Enteral stenting is used increasingly as a palliative treatment of gastrointestinal malignant or non-malignant obstructions. This aim of this study was to evaluate the role of endoscopic stent implantation for palliation of acute colorectal cancer obstruction in critical patients.
This study was performed prospectively with 8 patients suffering clinical manifestations of acute bowel obstruction with severe co-morbid diseases that caused them to be inoperable. They were treated by semi-elective stent insertion after primary resuscitation. Gentle dilation of stricture with balloon or buginage was performed under fluoroscopy and colonoscopy in gastrointestinal ward without complete preparation. Then an uncovered self-expanding metal stent was inserted over guide wire in the location of the tumor.
Endoscopic stent implantation could be successfully performed in six patients. In early days after stent insertion; general condition of patients gradually improved, and symptoms of acute obstruction was relieved. In two of the cases stent was inserted with difficulty due to very tortuous and complex strictures. Complications of stenting in this study were very rare. Displacement of stent after successful insertion was not seen. Of our studied patients, two died after 2 months, one after 4 months and three of them after 7-8 months. The cause of death in these patients was advanced metastatic lesion in liver, lung, bone and severe underlying disease such as heart failure.
Endoscopic stent implantation seems to be an effective and safe palliative approach for management of emergency conditions of acute colonic obstruction in inoperable patients with advanced colorectal cancer.
肠道支架置入术越来越多地被用作胃肠道恶性或非恶性梗阻的姑息治疗方法。本研究的目的是评估内镜下支架置入术在缓解重症患者急性结直肠癌梗阻中的作用。
本研究前瞻性纳入8例有急性肠梗阻临床表现且伴有严重合并症而无法进行手术的患者。在初步复苏后对他们进行半选择性支架置入术。在未完全准备的情况下,于胃肠病房在荧光透视和结肠镜检查下用球囊或探条轻柔扩张狭窄部位。然后在肿瘤部位经导丝置入无覆膜自膨式金属支架。
6例患者成功完成内镜下支架置入术。支架置入后的早期,患者的一般状况逐渐改善,急性梗阻症状得到缓解。其中2例因狭窄部位极其迂曲复杂而置入支架困难。本研究中支架置入的并发症非常罕见。成功置入后未见支架移位。在我们研究的患者中,2例在2个月后死亡,1例在4个月后死亡,3例在7 - 8个月后死亡。这些患者的死亡原因是肝、肺、骨的晚期转移病灶以及严重的基础疾病如心力衰竭。
对于晚期结直肠癌无法手术的患者,内镜下支架置入术似乎是治疗急性结肠梗阻紧急情况的一种有效且安全的姑息方法。