Department of Cardiac Ultrasound, Institute of Angiocardiopathy of Hunan, Xiangya Second Hospital, Central South University, Changsha 410011, PR China.
Int J Biol Macromol. 2010 Apr 1;46(3):284-8. doi: 10.1016/j.ijbiomac.2010.01.016. Epub 2010 Jan 25.
Age is a major risk factor for cardiovascular disease including heart disease. The aim of this study was to investigate chemical composition and structure of Auricularia auricula polysaccharides and its effect in improving heart function by examining blood and heart antioxidant enzyme activity and heart function parameters, e.g. left ventricle ejection fraction (EF), Left ventricular short axis fractional shortening (FS) in aged mice after giving the polysaccharides 40 days. GC-MS showed that monosaccharide composition of A. auricula polysaccharides was glucose (72%), mannose (8%), xylose (10%) and fucose (10%). FT-IR spectra obtained from A. auricula polysaccharides had peaks at about 3500 cm(-1) and 500 cm(-1) in the carbohydrate region. These are characteristic of polysaccharides. In all spectra, the absorption between 1500 cm(-1) and 670 cm(-1) may be attributed to bands of C-H, C-O and O-H in the polysaccharides. Pharmacological experiment indicated that aged mice showed a significant (P<0.01) decline in immune, antioxidant activities, EF and FS values. All abnormal immune, antioxidant enzymes, EF and FS parameters tested in aged mice were greatly (P<0.01) ameliorated following A. auricula polysaccharides administration. In conclusion, A. auricula polysaccharides treatment could improve heart function through its strong antioxidant activity.
年龄是心血管疾病（包括心脏病）的一个主要危险因素。本研究旨在通过检查血液和心脏抗氧化酶活性以及心脏功能参数，如左心室射血分数（EF）和左心室短轴缩短分数（FS），来研究银耳多糖的化学组成和结构及其改善心脏功能的作用。给予多糖 40 天后，衰老小鼠。GC-MS 表明，银耳多糖的单糖组成是葡萄糖（72%）、甘露糖（8%）、木糖（10%）和岩藻糖（10%）。从银耳多糖获得的 FT-IR 光谱在碳水化合物区域具有约 3500 cm(-1) 和 500 cm(-1) 的峰。这些是多糖的特征。在所有光谱中，1500 cm(-1) 和 670 cm(-1) 之间的吸收可能归因于多糖中 C-H、C-O 和 O-H 的带。药理实验表明，衰老小鼠的免疫、抗氧化活性、EF 和 FS 值明显下降（P<0.01）。给予银耳多糖后，衰老小鼠所有异常的免疫、抗氧化酶、EF 和 FS 参数均得到显著改善（P<0.01）。总之，银耳多糖治疗可通过其强大的抗氧化活性改善心脏功能。
