Department of Computer Science, Ben Gurion University of the Negev, P.O.B 653 Be'er Sheva 84105, Israel.
J Biomol Struct Dyn. 2010 Aug;28(1):107-22. doi: 10.1080/07391102.2010.10507347.
Nucleosome DNA bendability pattern extracted from large nucleosome DNA database of C. elegans is used for construction of full length (116 dinucleotide positions) nucleosome DNA bendability matrix. The matrix can be used for sequence-directed mapping of the nucleosomes on the sequences. Several alternative positions for a given nucleosome are typically predicted, separated by multiples of nucleosome DNA period. The corresponding computer program is successfully tested on best known experimental examples of accurately positioned nucleosomes. The uncertainty of the computational mapping is +/-1 base. The procedure is placed on publicly accessible server and can be applied to any DNA sequence of interest.
从秀丽隐杆线虫的大型核小体 DNA 数据库中提取核小体 DNA 弯曲性模式，用于构建全长（116 个二核苷酸位置）核小体 DNA 弯曲性矩阵。该矩阵可用于序列导向的核小体在序列上的作图。通常会预测给定核小体的几个替代位置，它们由核小体 DNA 周期的倍数隔开。相应的计算机程序已成功应用于经过精确定位的核小体的最佳已知实验示例进行测试。计算作图的不确定性为 +/-1 个碱基。该程序放置在公共访问服务器上，可应用于任何感兴趣的 DNA 序列。
