School of Optometry, University of Waterloo, Waterloo, Ontario, Canada.
Invest Ophthalmol Vis Sci. 2010 May;51(5):2381-7. doi: 10.1167/iovs.09-4188. Epub 2010 Jan 27.
To compare the clinical presentation of 231 patients with primary Sjögren's syndrome (pSS) with 89 patients with aqueous-deficient dry eye (keratoconjunctivitis sicca; KCS), to determine those procedures that best differentiate these groups in the eye care clinic.
The records of all patients seen at the University Health Network Sjögren's Syndrome Clinic from October 1992 to July 2006 were reviewed and documented. The diagnosis of pSS was based on the AECC (American European Consensus Criteria) of 2002. KCS control subjects were non-SS patients with symptoms of dry eye and Schirmer scores of <or=10 mm in 5 minutes in at least one eye. There were 90 variables used in the analysis of the total database. Recursive partitioning was used to generate tree diagrams that demonstrated which characteristics best distinguished pSS from KCS.
Recursive partitioning of the full database demonstrated that the serum immunoglobulin Ro and the status of the salivary gland biopsy were most important in distinguishing pSS and KCS. The presence of rose bengal staining of the temporal conjunctiva was the most important noninvasive ocular variable that separated the groups. Total rose bengal staining also improved sensitivity. When only noninvasive techniques were used, staining of the temporal conjunctiva and severity of dry mouth symptoms were the major factors in distinguishing pSS from KCS.
Rose bengal staining of the ocular surface is an important observation in the detection of SS and the differentiation of pSS and KCS.
比较 231 例原发性干燥综合征（pSS）患者和 89 例水样液缺乏性干眼症（干眼病；KCS）患者的临床表现，以确定在眼科诊所中能最好地区分这两组的检查方法。
对 1992 年 10 月至 2006 年 7 月在多伦多大学健康网络干燥综合征诊所就诊的所有患者的记录进行了回顾和记录。pSS 的诊断基于 2002 年美国欧洲共识标准（AECC）。KCS 对照组为有干眼症状且至少一眼 5 分钟 Schirmer 评分＜=10mm 的非 SS 患者。在对整个数据库的分析中使用了 90 个变量。递归分割用于生成树状图，以显示哪些特征最能区分 pSS 和 KCS。
全数据库的递归分割表明，血清免疫球蛋白 Ro 和唾液腺活检的状态在区分 pSS 和 KCS 中最重要。颞侧结膜的玫瑰红染色是分离两组的最重要的非侵入性眼部变量。总玫瑰红染色也提高了敏感性。当仅使用非侵入性技术时，颞侧结膜染色和口干症状的严重程度是区分 pSS 和 KCS 的主要因素。
眼表的玫瑰红染色是检测 SS 和区分 pSS 和 KCS 的一个重要观察指标。
