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干燥综合征中的泪液蛋白质

Tear fluid proteins in Sjögren's syndrome.

作者信息

Janssen P T, van Bijsterveld O P

出版信息

Scand J Rheumatol Suppl. 1986;61:224-7.

PMID:3473637
Abstract

Schirmer-I test, rose bengal staining and BUT in normals, keratoconjunctivitis sicca patients and patients with Sjögren's syndrome were compared with the results of lactoferrin, lysozyme and tear-specific prealbumin assays as diagnostic procedures for lacrimal gland function. The results suggest that all three major tear proteins, originating from the tear gland can serve as sensitive markers for lacrimal gland function. In clinical practice the simple immunodiffusion assay for lactoferrin could be a reliable alternative for the traditional diagnostic tests.

摘要

将正常受试者、干燥性角结膜炎患者和干燥综合征患者的Schirmer - I试验、孟加拉玫瑰红染色和泪膜破裂时间,与乳铁蛋白、溶菌酶和泪液特异性前白蛋白检测结果进行比较,以作为泪腺功能的诊断方法。结果表明,源自泪腺的所有三种主要泪液蛋白都可作为泪腺功能的敏感标志物。在临床实践中,用于乳铁蛋白的简单免疫扩散试验可能是传统诊断测试的可靠替代方法。

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1
Tear fluid proteins in Sjögren's syndrome.干燥综合征中的泪液蛋白质
Scand J Rheumatol Suppl. 1986;61:224-7.
2
The diagnostic power of the tests for tear gland related keratoconjunctivitis sicca.针对泪腺相关性干燥性角结膜炎的检测诊断效能。
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Tear glycoprotein determinations in the diagnosis and differential diagnosis of dry eyes.泪液糖蛋白测定在干眼症诊断及鉴别诊断中的应用
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Comparison of lacrimal and salivary gland involvement in Sjögren's syndrome.干燥综合征中泪腺和唾液腺受累情况的比较。
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Rose bengal staining of the temporal conjunctiva differentiates Sjögren's syndrome from keratoconjunctivitis sicca.颞部结膜的孟加拉玫瑰红染色可将干燥性角结膜炎与干燥综合征区分开来。
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Prospective studies on the progress of sicca symptoms in Sjögren's syndrome: subclinical disease develops into the clinical syndrome.干燥综合征中干燥症状进展的前瞻性研究:亚临床疾病发展为临床综合征。
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Primary Sjögren's syndrome and keratoconjunctivitis sicca: diagnostic methods, frequency and social disease aspects.原发性干燥综合征与干燥性角结膜炎:诊断方法、发病率及社会疾病相关方面
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引用本文的文献

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Invest Ophthalmol Vis Sci. 2020 Dec 1;61(14):19. doi: 10.1167/iovs.61.14.19.
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Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patients.Cathepsin S 活性增加与蛋白酶抑制能力降低相关,导致干燥综合征患者的泪液蛋白发生改变。
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Proteomic analysis revealed the altered tear protein profile in a rabbit model of Sjögren's syndrome-associated dry eye.蛋白质组学分析揭示了干燥综合征相关干眼兔模型中泪液蛋白谱的改变。
Proteomics. 2013 Aug;13(16):2469-81. doi: 10.1002/pmic.201200230.
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A novel fluorescent lipid probe for dry eye: retrieval by tear lipocalin in humans.一种新型干眼症荧光脂质探针:人眼通过泪液中的脂联素回收。
Invest Ophthalmol Vis Sci. 2013 Feb 19;54(2):1398-410. doi: 10.1167/iovs.12-10817.
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Tear lipocalin captures exogenous lipid from abnormal corneal surfaces.泪乳铁蛋白从异常的角膜表面捕获外源性脂质。
Invest Ophthalmol Vis Sci. 2010 Apr;51(4):1981-7. doi: 10.1167/iovs.09-4622. Epub 2009 Dec 3.
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Tear lipocalin: evidence for a scavenging function to remove lipids from the human corneal surface.泪液脂质运载蛋白:清除人角膜表面脂质的清除功能证据。
Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3589-96. doi: 10.1167/iovs.05-0569.
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Decreased tear lactoferrin concentration in patients with chronic hepatitis C.慢性丙型肝炎患者泪液乳铁蛋白浓度降低。
Br J Ophthalmol. 1999 Jun;83(6):684-7. doi: 10.1136/bjo.83.6.684.
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Sjögren syndrome: comparative studies in local ocular and serum immunoglobulin concentrations with special reference to secretory IgA.干燥综合征:局部眼部和血清免疫球蛋白浓度的比较研究,特别提及分泌型IgA
Int Ophthalmol. 1991 May;15(3):147-51. doi: 10.1007/BF00153916.
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Clinical profiles of non dry eye patients and correlations with tear protein levels.非干眼患者的临床特征及其与泪液蛋白质水平的相关性。
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