Klaassen-Broekema N, Mackor A J, van Bijsterveld O P
University Hospital Utrecht, Netherlands.
Neth J Med. 1992 Apr;40(3-4):113-6.
Laboratory tear function tests, such as the lactoferrin and the lysozyme test, reflect the level of tear gland deficiency and are, therefore, very useful for the clinician in the diagnosis of keratoconjunctivitis sicca (KCS). Although these tests do have an excellent discriminatory ability, they should be used in addition to clinical tests, such as the Schirmer-1 test, the tear film break-up time (BUT) and the Rose bengal (Rb) staining test. Schirmer's test, the most commonly used clinical test, measures tear fluid production. The tear film BUT, on the other hand, is the only test which establishes tear film instability. The Rose bengal score is strongly related to secondary damage of the superficial epithelium of the cornea and conjunctiva in patients with KCS. Thus, combining the results of these various tests facilitates the diagnosis of KCS and also the differentiation between Sjögren's KCS and non-Sjögren's KCS.
实验室泪液功能测试，如乳铁蛋白和溶菌酶测试，反映泪腺缺乏程度，因此对临床医生诊断干眼症（KCS）非常有用。尽管这些测试具有出色的鉴别能力，但应与临床测试一起使用，如Schirmer-1测试、泪膜破裂时间（BUT）和孟加拉玫瑰红（Rb）染色测试。Schirmer测试是最常用的临床测试，用于测量泪液分泌量。另一方面，泪膜BUT是唯一能确定泪膜稳定性的测试。孟加拉玫瑰红评分与KCS患者角膜和结膜浅表上皮的继发性损伤密切相关。因此，综合这些不同测试的结果有助于KCS的诊断，也有助于区分干燥综合征相关性KCS和非干燥综合征相关性KCS。
