双吲哚甲酰胺对G-四链体的识别
G-quadruplex recognition by bis-indole carboxamides.
作者信息
Dash Jyotirmayee, Shirude Pravin S, Balasubramanian Shankar
机构信息
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
出版信息
Chem Commun (Camb). 2008 Jul 14(26):3055-7. doi: 10.1039/b806042h. Epub 2008 Jun 5.
Abstract
Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.
摘要
在此，我们报告了一种几何结构灵活的双吲哚羧酰胺及其受限衍生物的从头设计与合成，它们是一类新型的小分子支架，对与c - kit2和c - myc启动子相关的DNA G - 四链体序列具有很高的稳定潜力。
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