Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, DK-2900 Hellerup, Denmark.
Acta Derm Venereol. 2010;90(1):27-33. doi: 10.2340/00015555-0772.
There is evidence that stimulants such as alcohol and tobacco have an effect on the immune system, but little is known about how these lifestyle factors affect the prevalence of contact sensitization. This study investigated whether smoking and alcohol consumption were associated with contact sensitization and nickel sensitization. A random sample of adults (n=3460) from the general population of Copenhagen was invited to participate in a general health examination including patch-testing. Alcohol consumption was not associated with nickel sensitization, whereas a significant trend (p<0.05) was identified between smoking status and nickel sensitization in an adjusted model; i.e. nickel sensitization was higher among both previous smokers (odds ratio (OR) = 1.19; confidence interval (CI) = 0.81-1.76), current light smokers (OR=1.50; CI=0.94-2.37) and current heavy smokers (OR=1.56; CI = 0.87-2.80) compared with never smokers. This study confirmed that smoking is associated with nickel sensitization, but rejected an association with alcohol consumption.
有证据表明，酒精和烟草等兴奋剂会对免疫系统产生影响，但人们对这些生活方式因素如何影响接触致敏的流行知之甚少。本研究调查了吸烟和饮酒是否与接触致敏和镍致敏有关。哥本哈根普通人群的随机样本（n=3460）被邀请参加一项包括斑贴试验的一般健康检查。饮酒与镍致敏无关，而在调整后的模型中，吸烟状况与镍致敏之间存在显著趋势（p<0.05）；也就是说，以前吸烟者（比值比（OR）=1.19；置信区间（CI）=0.81-1.76）、当前轻度吸烟者（OR=1.50；CI=0.94-2.37）和当前重度吸烟者（OR=1.56；CI=0.87-2.80）镍致敏的比例均高于从不吸烟者。本研究证实吸烟与镍致敏有关，但拒绝了与饮酒有关的关联。
