Bachmann O, Länger F, Rademacher J
Klinik für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625, Hannover, Deutschland.
Internist (Berl). 2010 Mar;51 Suppl 1:264-8. doi: 10.1007/s00108-009-2504-x.
Pulmonary disease is a rare complication of inflammatory bowel disease. Airway inflammation, interstitial lung disease and several other manifestations have been described, and typical symptoms are productive cough, chest pain, and progressive dyspnea. Due to the frequency of preceding pulmonary disease and the common temporal dissociation regarding intestinal disease, pulmonary manifestations of inflammatory bowel disease are at high risk of being overlooked. If suspected, early work-up including CT scan and bronchoscopy should be initiated, since the natural course often involves rapidly progressive lung damage. The best therapeutic results have been obtained with topic and systemic steroids, while classic immunosuppressants are commonly not efficacious. Several case reports describe a beneficial effect of infliximab.
肺部疾病是炎症性肠病的一种罕见并发症。气道炎症、间质性肺疾病和其他几种表现已被描述,典型症状为咳痰、胸痛和进行性呼吸困难。由于先前肺部疾病的发生率以及肠道疾病常见的时间分离,炎症性肠病的肺部表现很容易被忽视。如果怀疑有肺部疾病,应尽早进行包括CT扫描和支气管镜检查在内的检查,因为其自然病程往往会导致快速进展的肺损伤。局部和全身使用类固醇取得了最佳治疗效果,而经典免疫抑制剂通常无效。几例病例报告描述了英夫利昔单抗的有益作用。