美沙拉嗪诱发的过敏性肺炎。病例报告及文献综述。

Mesalamine-induced hypersensitivity pneumonitis. A case report and review of the literature.

作者信息

Sviri S, Gafanovich I, Kramer M R, Tsvang E, Ben-Chetrit E

机构信息

Division of Medicine, Hadassah University Hospital, Jerusalem, Israel.

出版信息

J Clin Gastroenterol. 1997 Jan;24(1):34-6. doi: 10.1097/00004836-199701000-00007.

DOI:10.1097/00004836-199701000-00007

PMID:9013348

Abstract

A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever. Symptoms improved after discontinuation of mesalamine. A rechallenge 3 months later caused similar pulmonary symptoms, confirming the association between the drug and the respiratory system. Mesalamine may cause hypersensitivity pneumonitis in patients with Crohn's disease.

摘要

一名49岁患有克罗恩病的男子，正在接受泼尼松和美沙拉嗪（5-氨基水杨酸）治疗，出现了呼吸窘迫和发热症状加重的情况。停用美沙拉嗪后症状有所改善。3个月后再次使用该药物引发了类似的肺部症状，证实了该药物与呼吸系统之间的关联。美沙拉嗪可能会导致克罗恩病患者发生过敏性肺炎。