Genetics Institute, Ben-Gurion University of the Negev, Beersheba, Israel.
Eur Arch Otorhinolaryngol. 2010 Aug;267(8):1273-6. doi: 10.1007/s00405-010-1204-4. Epub 2010 Jan 28.
Tongue squamous cell carcinoma (SCC) has an increasing incidence, a high morbidity rate, and a 50% 5-year survival rate. The prognosis of tongue SCC is poor compared to SCC originating at other sites in the oral cavity, because they represent different biological subentities. Cytogenetic studies of head and neck SCC showed more losses than gains of various chromosomes or chromosomal segments. Among the frequent alterations there are losses of -4, -10, -13, -14, -18, -19, -21, -22, gains of +7, +8, +9, +16, +18, +20, and isochromosomes i(1q), i(3q), i(5p), i(8q). We are unaware of cytogenetic reports describing t(12;14) in tongue SCC. This is a cytogenetic study of SCC of the tongue. Tongue biopsy tissue was minced and cultured in RPMI-1640 medium. Cells were fixed and stained, and cytogenetic analysis performed according to standard procedures. A clone with t(12;14) along with other random numerical chromosomal changes was found in a case of tongue SCC. The significance of t(12;14) in diagnosis or prognosis is not clear and should be further examined. Karyotyping of more tongue SCC cases will expand the knowledge regarding chromosomal aberrations in SCC and thus might shed light on the significance of t(12;14) shown in this study.
舌鳞状细胞癌（SCC）的发病率不断上升，发病率高，5 年生存率为 50％。与口腔其他部位起源的 SCC 相比，舌 SCC 的预后较差，因为它们代表不同的生物学亚实体。头颈部 SCC 的细胞遗传学研究表明，各种染色体或染色体片段存在更多的丢失而不是获得。在频繁改变的情况下，存在-4、-10、-13、-14、-18、-19、-21、-22 的丢失，+7、+8、+9、+16、+18、+20 和等臂染色体 i（1q）、i（3q）、i（5p）、i（8q）的获得。我们不知道描述舌 SCC 中的 t（12；14）的细胞遗传学报告。这是对舌 SCC 的细胞遗传学研究。将舌活检组织切成小块并在 RPMI-1640 培养基中培养。根据标准程序固定和染色细胞，并进行细胞遗传学分析。在舌 SCC 的一个病例中发现了带有 t（12；14）的克隆以及其他随机的数字染色体变化。t（12；14）在诊断或预后中的意义尚不清楚，需要进一步研究。对更多舌 SCC 病例进行染色体组型分析将扩展 SCC 中染色体异常的知识，从而可能揭示本研究中显示的 t（12；14）的意义。
