Geffen Noa, Norman Galia, Kheradiya Nisha S, Assia Ehud I
Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel.
Isr Med Assoc J. 2009 Nov;11(11):664-8.
It is common practice to use topical antiseptic formulations prior to specific therapy in superficial infections and injuries, but not in corneal bacterial ulcers. There is accumulating evidence proving chlorhexidine gluconate 0.02%, an antiseptic agent, as an effective treatment for infectious keratitis.
To investigate the safety and efficacy of chlorhexidine gluconate 0.02% as an adjunct therapy for corneal bacterial ulcers.
Twenty-six patients with corneal bacterial ulcers were treated with standard empirical antibiotic treatment. The study group was treated with chlorhexidine gluconate 0.02% while controls received placebo for one week. The patients were followed for at least 1 month.
No allergic or toxic reactions were noted. Although a higher baseline severity of ulcers existed in the study group, no differences were found in final vision, scarring extent, or recovery duration.
Chlorhexidine gluconate 0.02% may improve the clinical course of corneal ulcers.
在浅表感染和损伤的特定治疗前使用局部抗菌制剂是常见做法，但在角膜细菌性溃疡治疗中并非如此。越来越多的证据表明，0.02%葡萄糖酸氯己定这种抗菌剂可有效治疗感染性角膜炎。
研究0.02%葡萄糖酸氯己定作为角膜细菌性溃疡辅助治疗的安全性和有效性。
26例角膜细菌性溃疡患者接受标准经验性抗生素治疗。研究组使用0.02%葡萄糖酸氯己定治疗，对照组接受安慰剂治疗，为期1周。对患者进行至少1个月的随访。
未观察到过敏或毒性反应。尽管研究组溃疡的基线严重程度较高，但在最终视力、瘢痕形成程度或恢复持续时间方面未发现差异。
0.02%葡萄糖酸氯己定可能改善角膜溃疡的临床病程。
