Department of Neurology, University Hospital of Münster, Albert-Schweitzer-Strafle 33, D-48149 Münster, Germany.
Best Pract Res Clin Anaesthesiol. 2009 Dec;23(4):473-85. doi: 10.1016/j.bpa.2009.09.002.
Tight glycaemic control (TGC) for patients treated in an intensive care unit ICU is associated with an increased risk for hypoglycaemia. Since hypoglycaemia mainly occurs in the sickest patients, no matter whether TGC is applied or not, it might be a marker for severity of illness or a harmful event in itself. Furthermore, it remains a matter of debate whether harmful effects of hypoglycaemia outbalance the clinical benefits of TGC. This review focusses on the clinical manifestations of hypoglycaemia in the critically ill and highlights its potential short- and long-term consequences specifically concerning neurocognitive function.
重症监护病房（ICU）患者的严格血糖控制（TGC）与低血糖风险增加有关。由于低血糖主要发生在病情最严重的患者中，无论是否应用 TGC，它可能是疾病严重程度的标志物，或者本身就是一种有害事件。此外，低血糖的有害影响是否超过 TGC 的临床获益，仍存在争议。本综述重点关注危重症患者低血糖的临床表现，并特别强调其对神经认知功能的潜在短期和长期后果。
