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摄入含松油和异丙醇的家用清洁剂致死。

A lethal ingestion of a household cleaner containing pine oil and isopropanol.

机构信息

Provincial Toxicology Centre, 655 West 12th Avenue, Vancouver, British Columbia, Canada, V5Z 4R4.

出版信息

J Anal Toxicol. 2010 Jan-Feb;34(1):49-52. doi: 10.1093/jat/34.1.49.

DOI:10.1093/jat/34.1.49
PMID:20109303
Abstract

This paper presents the case of a woman with a history of schizophrenia found deceased in her residence after she apparently ingested an unknown quantity of a pine oil-containing product. A strong lemon-pine odor emanated from the body. Autopsy revealed a large volume of oily fluid in the stomach. The lungs were heavy, hemorrhagic, and necrotic. There was no evidence of significant recent injury or pre-existing disease. The toxicological screening and quantitation of 1-alpha-terpineol in postmortem fluids was performed by gas chromatography-mass spectrometry. Isopropanol and its metabolite acetone were determined by means of flame-ionization gas chromatography. Postmortem blood, urine, and stomach content levels of 1-alpha-terpineol were 276 mg/L, 0.5 mg/L, and 4.0 g/total contents, respectively, and isopropanol levels were 730 mg/dL, 20 mg/dL, and 1000 mg/dL, respectively. No acetone could be detected. Her death was attributed to the combined toxicity of isopropanol and pine oil.

摘要

本文报道了一例精神分裂症病史的女性,在其住所被发现死亡,显然摄入了未知数量的松油产品。尸体散发出强烈的柠檬-松木气味。尸检显示胃中有大量油性液体。肺脏沉重、出血和坏死。没有明显的近期损伤或先前存在的疾病的证据。通过气相色谱-质谱法对死后体液中的 1-α-松油醇进行了毒理学筛选和定量。通过火焰离子化气相色谱法测定异丙醇及其代谢物丙酮。死后血液、尿液和胃内容物中 1-α-松油醇的浓度分别为 276mg/L、0.5mg/L 和 4.0g/总含量,异丙醇浓度分别为 730mg/dL、20mg/dL 和 1000mg/dL,均未检测到丙酮。她的死亡归因于异丙醇和松油的联合毒性。

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Putatively lethal ingestion of isopropyl alcohol-related case: interpretation of post mortem isopropyl alcohol and acetone concentrations remains challenging.疑似致命性摄入异丙醇相关案例:死后异丙醇和丙酮浓度的解读仍然具有挑战性。
Int J Legal Med. 2021 Jan;135(1):175-182. doi: 10.1007/s00414-020-02444-4. Epub 2020 Oct 22.
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The Activation Effects of Low Level Isopropyl Alcohol Exposure on Arterial Blood Pressures Are Associated with Decreased 5-Hydroxyindole Acetic Acid in Urine.
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PLoS One. 2016 Sep 13;11(9):e0162762. doi: 10.1371/journal.pone.0162762. eCollection 2016.