Austad S N
University of Idaho, Department of Biological Sciences, Moscow 83844-3051, USA.
Exp Gerontol. 1997 Jan-Apr;32(1-2):23-38. doi: 10.1016/s0531-5565(96)00059-9.
A comparative assessment of aging and longevity in mammals has four uses in aging research. These are: (1) hypothesis formulation and evaluation, (2) investigating the generality of putative aging mechanisms, (3) isolating key physiological factors influencing aging rate, and (4) allowing the most appropriate choice of animal models for particular research questions. The first use requires detailed information on a wide variety of species, and I will examine general patterns of aging in a sample of over 600 species of mammals. The second use requires the selection of several models as distantly related to one another as feasible. The third use is best served by evaluating species or populations as closely related to one another as possible, assuming that they differ substantially in aging rate. The fourth use requires a logic of animal model selection, as well detailed information about a wide range of species. Specific examples of each use will be given.
对哺乳动物衰老和寿命的比较评估在衰老研究中有四个用途。它们是：（1）假设的形成与评估；（2）研究假定衰老机制的普遍性；（3）分离影响衰老速率的关键生理因素；（4）为特定研究问题选择最合适的动物模型。第一种用途需要关于多种物种的详细信息，我将研究600多种哺乳动物样本中的衰老一般模式。第二种用途需要尽可能选择彼此亲缘关系较远的几种模型。第三种用途最好通过评估彼此亲缘关系尽可能近的物种或种群来实现，前提是它们在衰老速率上有很大差异。第四种用途需要动物模型选择的逻辑以及关于广泛物种的详细信息。将给出每种用途的具体示例。
