Department of Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8108, St. Louis, Missouri, USA.
Adv Genet. 2009;68:57-81. doi: 10.1016/S0065-2660(09)68003-2. Epub 2010 Jan 13.
Social experience alters the expression of genes related to synaptic function and plasticity, induces elaborations in the morphology of neural structures throughout the brain (Volkmar and Greenough, 1972; Greenough et al., 1978; Technau, 2007), improves cognitive and behavioral performance (Pham et al., 1999a; Toscano et al., 2006) and alters subsequent sleep (Ganguly-Fitzgerald et al., 2006). In this review, we discuss the plastic mechanisms that are induced in response to social experience and how social enrichment can provide insight into the biological functions of sleep.
社会经验改变了与突触功能和可塑性相关的基因表达,诱导了大脑中神经结构形态的精细化(Volkmar 和 Greenough,1972;Greenough 等人,1978;Technau,2007),提高了认知和行为表现(Pham 等人,1999a;Toscano 等人,2006),并改变了随后的睡眠(Ganguly-Fitzgerald 等人,2006)。在这篇综述中,我们讨论了响应社会经验而诱导的可塑性机制,以及社会丰富度如何为睡眠的生物学功能提供新的见解。