哺乳动物静止和活跃的成年干细胞共存。
Coexistence of quiescent and active adult stem cells in mammals.
机构信息
Stowers Institute for Medical Research (SIMR), Kansas City, MO 64110, USA.
出版信息
Science. 2010 Jan 29;327(5965):542-5. doi: 10.1126/science.1180794.
Abstract
Adult stem cells are crucial for physiological tissue renewal and regeneration after injury. Prevailing models assume the existence of a single quiescent population of stem cells residing in a specialized niche of a given tissue. Emerging evidence indicates that both quiescent (out of cell cycle and in a lower metabolic state) and active (in cell cycle and not able to retain DNA labels) stem cell subpopulations may coexist in several tissues, in separate yet adjoining locations. Here, we summarize these findings and propose that quiescent and active stem cell populations have separate but cooperative functional roles.
摘要
成体干细胞对于生理组织在损伤后的更新和再生至关重要。主流模型假设存在一个静止的单一干细胞群体，存在于特定组织的专门龛位中。新出现的证据表明，静止（处于细胞周期之外且代谢状态较低）和活跃（处于细胞周期中且无法保留 DNA 标记）的干细胞亚群可能存在于多个组织中，位于不同但相邻的位置。在这里，我们总结了这些发现，并提出静止和活跃的干细胞群体具有独立但协作的功能作用。
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本文引用的文献
1
Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells.在不常分裂的毛囊干细胞微环境中存在不同的自我更新和分化阶段。
Cell Stem Cell. 2009 Sep 4;5(3):267-78. doi: 10.1016/j.stem.2009.06.004. Epub 2009 Aug 6.
2
The tortoise and the hair: slow-cycling cells in the stem cell race.龟兔赛跑：干细胞竞争中的慢循环细胞
Cell. 2009 May 29;137(5):811-9. doi: 10.1016/j.cell.2009.05.002.
3
Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones.通过长骨活体延时成像揭示老年早期造血祖细胞的细胞动力学改变及骨内膜定位。
Blood. 2009 Jul 9;114(2):290-8. doi: 10.1182/blood-2008-12-195644. Epub 2009 Apr 8.
4
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.单个Lgr5干细胞在体外无需间充质微环境即可构建隐窝-绒毛结构。
Nature. 2009 May 14;459(7244):262-5. doi: 10.1038/nature07935. Epub 2009 Mar 29.
5
Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion.小肠上皮细胞对通过缺失细胞周期蛋白依赖性激酶25（CDC25）导致的细胞分裂急性破坏的反应。
Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4701-6. doi: 10.1073/pnas.0900751106. Epub 2009 Mar 9.
6
A two-step mechanism for stem cell activation during hair regeneration.毛发再生过程中干细胞激活的两步机制。
Cell Stem Cell. 2009 Feb 6;4(2):155-69. doi: 10.1016/j.stem.2008.12.009.
7
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Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells.组蛋白2B-绿色荧光蛋白保留分析揭示了缓慢循环的造血干细胞。
Nat Biotechnol. 2009 Jan;27(1):84-90. doi: 10.1038/nbt.1517. Epub 2008 Dec 5.
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Detection of functional haematopoietic stem cell niche using real-time imaging.利用实时成像技术检测功能性造血干细胞龛位。
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