哺乳动物静止和活跃的成年干细胞共存。
Coexistence of quiescent and active adult stem cells in mammals.
机构信息
Stowers Institute for Medical Research (SIMR), Kansas City, MO 64110, USA.
出版信息
Science. 2010 Jan 29;327(5965):542-5. doi: 10.1126/science.1180794.
Abstract
Adult stem cells are crucial for physiological tissue renewal and regeneration after injury. Prevailing models assume the existence of a single quiescent population of stem cells residing in a specialized niche of a given tissue. Emerging evidence indicates that both quiescent (out of cell cycle and in a lower metabolic state) and active (in cell cycle and not able to retain DNA labels) stem cell subpopulations may coexist in several tissues, in separate yet adjoining locations. Here, we summarize these findings and propose that quiescent and active stem cell populations have separate but cooperative functional roles.
摘要
成体干细胞对于生理组织在损伤后的更新和再生至关重要。主流模型假设存在一个静止的单一干细胞群体，存在于特定组织的专门龛位中。新出现的证据表明，静止（处于细胞周期之外且代谢状态较低）和活跃（处于细胞周期中且无法保留 DNA 标记）的干细胞亚群可能存在于多个组织中，位于不同但相邻的位置。在这里，我们总结了这些发现，并提出静止和活跃的干细胞群体具有独立但协作的功能作用。
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