龟兔赛跑：干细胞竞争中的慢循环细胞
The tortoise and the hair: slow-cycling cells in the stem cell race.
作者信息
Fuchs Elaine
机构信息
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA.
出版信息
Cell. 2009 May 29;137(5):811-9. doi: 10.1016/j.cell.2009.05.002.
Abstract
Given the importance of stem cells to adult tissues, it has long been postulated that stem cells divide infrequently to preserve their long-term proliferation potential and to prevent the acquisition of errors during DNA replication. Yet, some stem cells must be able to continually churn out progeny in tissues that rapidly turn over or are subject to sudden injuries or growth spurts. This Review explores the challenges that mammalian stem cells face in balancing the competing demands of proliferation and differentiation in tissues.
摘要
鉴于干细胞对成体组织的重要性，长期以来人们一直推测干细胞很少分裂，以保持其长期增殖潜力，并防止在DNA复制过程中出现错误。然而，在快速更新或易受突然损伤或生长激增影响的组织中，一些干细胞必须能够持续产生后代。本综述探讨了哺乳动物干细胞在平衡组织中增殖和分化的相互竞争需求时所面临的挑战。
相似文献
1
The tortoise and the hair: slow-cycling cells in the stem cell race.
Cell. 2009 May 29;137(5):811-9. doi: 10.1016/j.cell.2009.05.002.
2
Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells.
Cold Spring Harb Symp Quant Biol. 2008;73:351-6. doi: 10.1101/sqb.2008.72.003.
3
Coexistence of quiescent and active adult stem cells in mammals.
Science. 2010 Jan 29;327(5965):542-5. doi: 10.1126/science.1180794.
4
Two anatomically distinct niches regulate stem cell activity.
Blood. 2012 Sep 13;120(11):2174-81. doi: 10.1182/blood-2012-04-424507. Epub 2012 Jul 11.
5
Adult hair follicle stem cells do not retain the older DNA strands in vivo during normal tissue homeostasis.
Chromosome Res. 2013 May;21(3):203-12. doi: 10.1007/s10577-013-9355-y.
6
Compartmentalized organization: a common and required feature of stem cell niches?
Development. 2010 May;137(10):1586-94. doi: 10.1242/dev.041103.
7
Have hair follicle stem cells shed their tranquil image?
Cell Stem Cell. 2008 Dec 4;3(6):581-2. doi: 10.1016/j.stem.2008.11.005.
8
Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation.
Development. 2008 Mar;135(6):1059-68. doi: 10.1242/dev.012799. Epub 2008 Feb 6.
9
Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches.
Nat Commun. 2012 Apr 17;3:784. doi: 10.1038/ncomms1784.
10
The interfollicular epidermal stem cell saga: sensationalism versus reality check.
Exp Dermatol. 2011 Sep;20(9):697-702. doi: 10.1111/j.1600-0625.2011.01338.x.
引用本文的文献
1
Stem/progenitor cell dynamics during salivary gland development and regeneration demonstrated by the double pulse-chase paradigm.
Regen Ther. 2025 Aug 13;30:595-605. doi: 10.1016/j.reth.2025.08.007. eCollection 2025 Dec.
2
Deciphering the Role of Functional Ion Channels in Cancer Stem Cells (CSCs) and Their Therapeutic Implications.
Int J Mol Sci. 2025 Aug 6;26(15):7595. doi: 10.3390/ijms26157595.
3
Generation of the Mouse Line Targeting Outer Bulge Hair Follicle Cells.
Int J Mol Sci. 2025 Mar 29;26(7):3165. doi: 10.3390/ijms26073165.
4
MCL‑1 safeguards activated hair follicle stem cells to enable adult hair regeneration.
Nat Commun. 2025 Mar 22;16(1):2829. doi: 10.1038/s41467-025-58150-5.
5
Feedback between stochastic gene networks and population dynamics enables cellular decision-making.
Sci Adv. 2024 May 24;10(21):eadl4895. doi: 10.1126/sciadv.adl4895.
6
SMAD2/3-SMYD2 and developmental transcription factors cooperate with cell-cycle inhibitors to guide tissue formation.
Protein Cell. 2025 Apr 18;16(4):260-285. doi: 10.1093/procel/pwae031.
7
Autologous Stem Cell-derived Therapies for Androgenetic Alopecia: A Systematic Review of Randomized Control Trials on Efficacy, Safety, and Outcomes.
Plast Reconstr Surg Glob Open. 2024 Feb 13;12(2):e5606. doi: 10.1097/GOX.0000000000005606. eCollection 2024 Feb.
8
The dermal papilla dilemma and potential breakthroughs in bioengineering hair follicles.
Cell Tissue Res. 2023 Feb;391(2):221-233. doi: 10.1007/s00441-022-03730-w. Epub 2022 Dec 23.
9
Pyruvate Kinase M2 Promotes Hair Regeneration by Connecting Metabolic and Wnt/β-Catenin Signaling.
Pharmaceutics. 2022 Dec 13;14(12):2774. doi: 10.3390/pharmaceutics14122774.
10
Role of quiescent cells in the homeostatic maintenance of the adult submandibular salivary gland.
iScience. 2022 Sep 2;25(10):105047. doi: 10.1016/j.isci.2022.105047. eCollection 2022 Oct 21.
本文引用的文献
1
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Nature. 2009 May 14;459(7244):262-5. doi: 10.1038/nature07935. Epub 2009 Mar 29.
2
Transcription factor achaete scute-like 2 controls intestinal stem cell fate.
Cell. 2009 Mar 6;136(5):903-12. doi: 10.1016/j.cell.2009.01.031.
3
Epidermal homeostasis: a balancing act of stem cells in the skin.
Nat Rev Mol Cell Biol. 2009 Mar;10(3):207-17. doi: 10.1038/nrm2636. Epub 2009 Feb 11.
4
A two-step mechanism for stem cell activation during hair regeneration.
Cell Stem Cell. 2009 Feb 6;4(2):155-69. doi: 10.1016/j.stem.2008.12.009.
5
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation.
Nature. 2009 Jan 29;457(7229):603-7. doi: 10.1038/nature07589. Epub 2008 Dec 17.
6
Crypt stem cells as the cells-of-origin of intestinal cancer.
Nature. 2009 Jan 29;457(7229):608-11. doi: 10.1038/nature07602. Epub 2008 Dec 17.
7
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.
Cell. 2008 Dec 12;135(6):1118-29. doi: 10.1016/j.cell.2008.10.048.
8
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells.
Nat Biotechnol. 2009 Jan;27(1):84-90. doi: 10.1038/nbt.1517. Epub 2008 Dec 5.
9
Mouse hematopoietic stem cell identification and analysis.
Cytometry A. 2009 Jan;75(1):14-24. doi: 10.1002/cyto.a.20674.
10
Lgr5 marks cycling, yet long-lived, hair follicle stem cells.
Nat Genet. 2008 Nov;40(11):1291-9. doi: 10.1038/ng.239. Epub 2008 Oct 12.
Zotero 插件