Fuchs Elaine
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA.
Cell. 2009 May 29;137(5):811-9. doi: 10.1016/j.cell.2009.05.002.
Given the importance of stem cells to adult tissues, it has long been postulated that stem cells divide infrequently to preserve their long-term proliferation potential and to prevent the acquisition of errors during DNA replication. Yet, some stem cells must be able to continually churn out progeny in tissues that rapidly turn over or are subject to sudden injuries or growth spurts. This Review explores the challenges that mammalian stem cells face in balancing the competing demands of proliferation and differentiation in tissues.
鉴于干细胞对成体组织的重要性，长期以来人们一直推测干细胞很少分裂，以保持其长期增殖潜力，并防止在DNA复制过程中出现错误。然而，在快速更新或易受突然损伤或生长激增影响的组织中，一些干细胞必须能够持续产生后代。本综述探讨了哺乳动物干细胞在平衡组织中增殖和分化的相互竞争需求时所面临的挑战。
