龟兔赛跑：干细胞竞争中的慢循环细胞
The tortoise and the hair: slow-cycling cells in the stem cell race.
作者信息
Fuchs Elaine
机构信息
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA.
出版信息
Cell. 2009 May 29;137(5):811-9. doi: 10.1016/j.cell.2009.05.002.
Abstract
Given the importance of stem cells to adult tissues, it has long been postulated that stem cells divide infrequently to preserve their long-term proliferation potential and to prevent the acquisition of errors during DNA replication. Yet, some stem cells must be able to continually churn out progeny in tissues that rapidly turn over or are subject to sudden injuries or growth spurts. This Review explores the challenges that mammalian stem cells face in balancing the competing demands of proliferation and differentiation in tissues.
摘要
鉴于干细胞对成体组织的重要性，长期以来人们一直推测干细胞很少分裂，以保持其长期增殖潜力，并防止在DNA复制过程中出现错误。然而，在快速更新或易受突然损伤或生长激增影响的组织中，一些干细胞必须能够持续产生后代。本综述探讨了哺乳动物干细胞在平衡组织中增殖和分化的相互竞争需求时所面临的挑战。
相似文献
1
The tortoise and the hair: slow-cycling cells in the stem cell race.龟兔赛跑：干细胞竞争中的慢循环细胞
Cell. 2009 May 29;137(5):811-9. doi: 10.1016/j.cell.2009.05.002.
2
Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells.来自循环Lgr5+阳性干细胞的小肠、结肠和毛囊的超长期自我更新。
Cold Spring Harb Symp Quant Biol. 2008;73:351-6. doi: 10.1101/sqb.2008.72.003.
3
Coexistence of quiescent and active adult stem cells in mammals.哺乳动物静止和活跃的成年干细胞共存。
Science. 2010 Jan 29;327(5965):542-5. doi: 10.1126/science.1180794.
4
Two anatomically distinct niches regulate stem cell activity.两个解剖学上不同的龛位调节干细胞活性。
Blood. 2012 Sep 13;120(11):2174-81. doi: 10.1182/blood-2012-04-424507. Epub 2012 Jul 11.
5
Adult hair follicle stem cells do not retain the older DNA strands in vivo during normal tissue homeostasis.在正常组织稳态中，成年毛囊干细胞不会在体内保留较旧的 DNA 链。
Chromosome Res. 2013 May;21(3):203-12. doi: 10.1007/s10577-013-9355-y.
6
Compartmentalized organization: a common and required feature of stem cell niches?分区组织：干细胞龛的常见且必需特征？
Development. 2010 May;137(10):1586-94. doi: 10.1242/dev.041103.
7
Have hair follicle stem cells shed their tranquil image?毛囊干细胞是否已摆脱其平静的形象？
Cell Stem Cell. 2008 Dec 4;3(6):581-2. doi: 10.1016/j.stem.2008.11.005.
8
Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation.Runx1调节毛囊干细胞的发育激活，但不调节损伤驱动的激活。
Development. 2008 Mar;135(6):1059-68. doi: 10.1242/dev.012799. Epub 2008 Feb 6.
9
Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches.通过干细胞及其龛位的重排实现完全功能性的毛囊再生。
Nat Commun. 2012 Apr 17;3:784. doi: 10.1038/ncomms1784.
10
The interfollicular epidermal stem cell saga: sensationalism versus reality check.滤泡间表皮干细胞传奇：耸人听闻还是现实检验。
Exp Dermatol. 2011 Sep;20(9):697-702. doi: 10.1111/j.1600-0625.2011.01338.x.
引用本文的文献
1
Stem/progenitor cell dynamics during salivary gland development and regeneration demonstrated by the double pulse-chase paradigm.双脉冲追踪范式揭示的唾液腺发育和再生过程中的干/祖细胞动态变化。
Regen Ther. 2025 Aug 13;30:595-605. doi: 10.1016/j.reth.2025.08.007. eCollection 2025 Dec.
2
Deciphering the Role of Functional Ion Channels in Cancer Stem Cells (CSCs) and Their Therapeutic Implications.解析功能性离子通道在癌症干细胞（CSCs）中的作用及其治疗意义。
Int J Mol Sci. 2025 Aug 6;26(15):7595. doi: 10.3390/ijms26157595.
3
Generation of the Mouse Line Targeting Outer Bulge Hair Follicle Cells.靶向毛囊外隆突细胞的小鼠品系的产生
Int J Mol Sci. 2025 Mar 29;26(7):3165. doi: 10.3390/ijms26073165.
4
MCL‑1 safeguards activated hair follicle stem cells to enable adult hair regeneration.髓细胞白血病‑1（MCL‑1）保护激活的毛囊干细胞以实现成年毛发再生。
Nat Commun. 2025 Mar 22;16(1):2829. doi: 10.1038/s41467-025-58150-5.
5
Feedback between stochastic gene networks and population dynamics enables cellular decision-making.随机基因网络与种群动态之间的反馈使细胞能够做出决策。
Sci Adv. 2024 May 24;10(21):eadl4895. doi: 10.1126/sciadv.adl4895.
6
SMAD2/3-SMYD2 and developmental transcription factors cooperate with cell-cycle inhibitors to guide tissue formation.SMAD2/3-SMYD2与发育转录因子协同细胞周期抑制剂来引导组织形成。
Protein Cell. 2025 Apr 18;16(4):260-285. doi: 10.1093/procel/pwae031.
7
Autologous Stem Cell-derived Therapies for Androgenetic Alopecia: A Systematic Review of Randomized Control Trials on Efficacy, Safety, and Outcomes.雄激素性脱发的自体干细胞衍生疗法：关于疗效、安全性和结果的随机对照试验的系统评价
Plast Reconstr Surg Glob Open. 2024 Feb 13;12(2):e5606. doi: 10.1097/GOX.0000000000005606. eCollection 2024 Feb.
8
The dermal papilla dilemma and potential breakthroughs in bioengineering hair follicles.真皮乳头困境与毛囊生物工程的潜在突破
Cell Tissue Res. 2023 Feb;391(2):221-233. doi: 10.1007/s00441-022-03730-w. Epub 2022 Dec 23.
9
Pyruvate Kinase M2 Promotes Hair Regeneration by Connecting Metabolic and Wnt/β-Catenin Signaling.丙酮酸激酶M2通过连接代谢和Wnt/β-连环蛋白信号促进毛发再生。
Pharmaceutics. 2022 Dec 13;14(12):2774. doi: 10.3390/pharmaceutics14122774.
10
Role of quiescent cells in the homeostatic maintenance of the adult submandibular salivary gland.静止细胞在成年下颌下唾液腺稳态维持中的作用。
iScience. 2022 Sep 2;25(10):105047. doi: 10.1016/j.isci.2022.105047. eCollection 2022 Oct 21.
本文引用的文献
1
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.单个Lgr5干细胞在体外无需间充质微环境即可构建隐窝-绒毛结构。
Nature. 2009 May 14;459(7244):262-5. doi: 10.1038/nature07935. Epub 2009 Mar 29.
2
Transcription factor achaete scute-like 2 controls intestinal stem cell fate.转录因子achaete scute样蛋白2控制肠道干细胞命运。
Cell. 2009 Mar 6;136(5):903-12. doi: 10.1016/j.cell.2009.01.031.
3
Epidermal homeostasis: a balancing act of stem cells in the skin.表皮稳态：皮肤中干细胞的平衡行为。
Nat Rev Mol Cell Biol. 2009 Mar;10(3):207-17. doi: 10.1038/nrm2636. Epub 2009 Feb 11.
4
A two-step mechanism for stem cell activation during hair regeneration.毛发再生过程中干细胞激活的两步机制。
Cell Stem Cell. 2009 Feb 6;4(2):155-69. doi: 10.1016/j.stem.2008.12.009.
5
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation.Prominin 1标记易发生肿瘤转化的肠道干细胞。
Nature. 2009 Jan 29;457(7229):603-7. doi: 10.1038/nature07589. Epub 2008 Dec 17.
6
Crypt stem cells as the cells-of-origin of intestinal cancer.隐窝干细胞作为肠癌的起源细胞。
Nature. 2009 Jan 29;457(7229):608-11. doi: 10.1038/nature07602. Epub 2008 Dec 17.
7
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.造血干细胞在稳态和修复过程中从休眠状态可逆地转变为自我更新状态。
Cell. 2008 Dec 12;135(6):1118-29. doi: 10.1016/j.cell.2008.10.048.
8
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells.组蛋白2B-绿色荧光蛋白保留分析揭示了缓慢循环的造血干细胞。
Nat Biotechnol. 2009 Jan;27(1):84-90. doi: 10.1038/nbt.1517. Epub 2008 Dec 5.
9
Mouse hematopoietic stem cell identification and analysis.小鼠造血干细胞的鉴定与分析。
Cytometry A. 2009 Jan;75(1):14-24. doi: 10.1002/cyto.a.20674.
10
Lgr5 marks cycling, yet long-lived, hair follicle stem cells.Lgr5标记循环的、但寿命长的毛囊干细胞。
Nat Genet. 2008 Nov;40(11):1291-9. doi: 10.1038/ng.239. Epub 2008 Oct 12.
Zotero 插件