Alzheimer's Corporation, Albuquerque, NM, USA.
J Alzheimers Dis. 2010;19(2):429-39. doi: 10.3233/JAD-2010-1229.
One hundred thirteen community dwelling subjects between the ages of 50 and 75 without dementia were recruited. A blind administrator randomly assigned 54 subjects to placebo and 59 to active treatment groups. The active treatment consisted of four months treatment with a complex antioxidant blend. Placebo treatment was an identical gel and bottle administered for four months. Forty-eight active subjects and 38 placebo subjects completed the study. Memory testing with a 50 part paired association test and a 20-word immediate recall test were significantly improved, p=0.015 and p=0.005 respectively. A secondary study of serum homocysteine was completed in 25 active treatment subjects and 17 placebo subjects. Significant reduction in serum homocysteine levels was seen in the active treatment subjects (p=0.005). A complex antioxidant blend taken over four months improves performance on two difficult memory tests in community dwelling elderly subjects. Furthermore, the antioxidant significantly reduced the serum homocysteine level in treatment group.
招募了 113 名年龄在 50 至 75 岁之间、无痴呆症的社区居住者。一名盲管理员将 54 名受试者随机分配到安慰剂组和 59 名活性治疗组。活性治疗包括四个月的复杂抗氧化剂混合物治疗。安慰剂治疗是一种相同的凝胶和瓶子，持续四个月。48 名活性受试者和 38 名安慰剂受试者完成了研究。记忆测试使用 50 部分配对联想测试和 20 个单词即时回忆测试，分别显著改善，p=0.015 和 p=0.005。对 25 名活性治疗受试者和 17 名安慰剂受试者进行了血清同型半胱氨酸的二次研究。活性治疗组的血清同型半胱氨酸水平显著降低（p=0.005）。在四个月的时间里，服用一种复杂的抗氧化混合物可以改善社区居住的老年受试者在两项困难的记忆测试中的表现。此外，抗氧化剂显著降低了治疗组的血清同型半胱氨酸水平。
