Jessen Frank, Feyen Ludger, Freymann Katrin, Tepest Ralf, Maier Wolfgang, Heun Reinhard, Schild Hans-H, Scheef Lukas
Department of Psychiatry, University of Bonn, Germany.
Neurobiol Aging. 2006 Dec;27(12):1751-6. doi: 10.1016/j.neurobiolaging.2005.10.010. Epub 2005 Nov 23.
To examine the biological basis of subjective memory impairment (SMI), defined as the feeling of memory worsening with normal memory performance, we measured the volume of the entorhinal cortex (EC) and the hippocampus in SMI subjects, patients with mild cognitive impairment (MCI), patients with Alzheimer's disease (AD) and healthy controls (CO). Compared with controls, the EC was smaller in the SMI group (left: p=0.060; right: p=0.045) and in the other two groups in the following order: CO>SMI>MCI>AD. The same sequence was observed with regard to hippocampal volumes, but the volume reduction of the left hippocampus in the SMI group only reached a trend towards significance (p=0.072) and the right was not significantly smaller compared with controls (p=0.37). Compared with controls the average (left/right) volume reduction of the EC was 18% (SMI), 26% (MCI) and 44% (AD). The mean volume reduction of the hippocampus was 6% (SMI), 16% (MCI) and 19% (AD). Our results mirror the temporal sequence of neurodegeneration in AD and support the concept of SMI as the first clinical manifestation of dementia.
为了研究主观记忆障碍（SMI，定义为记忆功能正常但感觉记忆变差）的生物学基础，我们测量了SMI受试者、轻度认知障碍（MCI）患者、阿尔茨海默病（AD）患者及健康对照者（CO）的内嗅皮质（EC）和海马体体积。与对照组相比，SMI组的EC较小（左侧：p = 0.060；右侧：p = 0.045），其他两组也较小，顺序如下：CO > SMI > MCI > AD。海马体体积也观察到相同顺序，但SMI组左侧海马体体积减小仅达到显著趋势（p = 0.072），右侧与对照组相比无显著减小（p = 0.37）。与对照组相比，EC平均（左右侧）体积减小分别为18%（SMI）、26%（MCI）和44%（AD）。海马体平均体积减小分别为6%（SMI）、16%（MCI）和19%（AD）。我们的结果反映了AD神经退行性变的时间顺序，并支持将SMI作为痴呆的首个临床表现这一概念。
