Department of Gastroenterology, Hepatology and Gastrointestinal Oncology, Bogenhausen Academic Teaching Hospital, Technical University of Munich, Munich, Germany.
Digestion. 2010;81(4):207-13. doi: 10.1159/000258662. Epub 2010 Jan 21.
In the literature, data on the effects of gender and age on the pressure data of anorectal manometry differ. Possible reasons are investigation of only small numbers of healthy people and comparison of only 2 groups with large age differences. In addition, data about the influence of gender or age on anorectal sensation are sparse. Therefore, the aim of the present study was to determine the influence of gender and age on anorectal manometry in a large healthy female and male cohort spanning a great age range.
Anorectal manometry was performed in 72 women and 74 men with a median age of 64 years in both groups (ranges: women 22-90 years; men 23-88 years). We determined mean anal resting and squeeze pressure as well as minimal rectal balloon volume for perception and for urge/desire to defecate. The Mann-Whitney U test was used to analyze for gender differences, regression analysis to search for age influences.
Squeeze pressure (p = 0.007) and perception threshold (p < 0.001) are significantly lower in females, while the mean resting pressure and urge threshold are similar in females and males. Mean resting pressure (women p < 0.0001; men p = 0.03) and mean squeeze pressure decrease (women p < 0.0001; men p = 0.004) with age. An age-related increase in sensory thresholds (= decreased rectal sensitivity) is only seen in females (perception threshold p = 0.01; urge threshold p = 0.04).
Most of the parameters measured by anorectal manometry (anal canal pressure, sensory thresholds) are influenced by gender and age. Therefore, the results of anorectal manometry must be interpreted in relation to sex- and age-adapted normal values.
文献中，关于性别和年龄对肛肠测压数据影响的数据存在差异。可能的原因是仅对少数健康人群进行了研究，并且仅比较了两组年龄差异较大的人群。此外，关于性别或年龄对肛肠感觉影响的数据也很少。因此，本研究旨在确定性别和年龄对跨越较大年龄范围的大型健康女性和男性队列的肛肠测压的影响。
对 72 名女性和 74 名男性进行肛肠测压，两组的中位年龄均为 64 岁（范围：女性 22-90 岁；男性 23-88 岁）。我们确定了平均肛门静息和收缩压以及最小直肠球囊容量，用于感知和排便紧迫感/欲望。使用 Mann-Whitney U 检验分析性别差异，使用回归分析搜索年龄影响。
女性的收缩压（p = 0.007）和感知阈值（p < 0.001）明显较低，而女性和男性的平均静息压力和排便紧迫感阈值相似。女性的平均静息压力（p < 0.0001；男性 p = 0.03）和平均收缩压（p < 0.0001；男性 p = 0.004）随年龄而降低。仅在女性中观察到感觉阈值（=直肠敏感性降低）与年龄相关的增加（感知阈值 p = 0.01；排便紧迫感阈值 p = 0.04）。
肛肠测压所测量的大多数参数（肛管压力、感觉阈值）受性别和年龄的影响。因此，肛肠测压的结果必须根据性别和年龄适应的正常值进行解释。
