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高效、温和、无溶剂合成苯环酰基哈尔明碱。

An efficient, mild and solvent-free synthesis of benzene ring acylated harmalines.

机构信息

H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.

出版信息

Molecules. 2009 Dec 28;15(1):68-82. doi: 10.3390/molecules15010068.

DOI:10.3390/molecules15010068
PMID:20110872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6257112/
Abstract

A facile synthesis of a series of benzene ring acylated analogues of harmaline has been achieved by Friedel-Crafts acylation under solvent-free conditions at room temperature using acyl halides/acid anhydrides and AlCl3. The reaction afforded 10- and 12-acyl analogues of harmaline in good yield, along with minor quantities of N-acyl-tryptamines and 8-acyl analogues of N-acyltryptamines.

摘要

通过在室温下无溶剂条件下使用酰卤/酸酐和 AlCl3 进行 Friedel-Crafts 酰化反应，简便地合成了一系列哈尔马琳苯环酰化类似物。该反应以良好的收率得到了 10-和 12-哈尔马琳酰化类似物，以及少量的 N-酰基色胺和 N-酰基色胺的 8-酰化类似物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd49/6257112/5673f692fba0/molecules-15-00068-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd49/6257112/cfd6c9bab30b/molecules-15-00068-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd49/6257112/b07bac0b54b2/molecules-15-00068-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd49/6257112/38924f350626/molecules-15-00068-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd49/6257112/5673f692fba0/molecules-15-00068-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd49/6257112/cfd6c9bab30b/molecules-15-00068-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd49/6257112/b07bac0b54b2/molecules-15-00068-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd49/6257112/38924f350626/molecules-15-00068-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd49/6257112/5673f692fba0/molecules-15-00068-g004.jpg

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本文引用的文献

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