高效、温和、无溶剂合成苯环酰基哈尔明碱。
An efficient, mild and solvent-free synthesis of benzene ring acylated harmalines.
机构信息
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
出版信息
Molecules. 2009 Dec 28;15(1):68-82. doi: 10.3390/molecules15010068.
Abstract
A facile synthesis of a series of benzene ring acylated analogues of harmaline has been achieved by Friedel-Crafts acylation under solvent-free conditions at room temperature using acyl halides/acid anhydrides and AlCl3. The reaction afforded 10- and 12-acyl analogues of harmaline in good yield, along with minor quantities of N-acyl-tryptamines and 8-acyl analogues of N-acyltryptamines.
摘要
通过在室温下无溶剂条件下使用酰卤/酸酐和 AlCl3 进行 Friedel-Crafts 酰化反应，简便地合成了一系列哈尔马琳苯环酰化类似物。该反应以良好的收率得到了 10-和 12-哈尔马琳酰化类似物，以及少量的 N-酰基色胺和 N-酰基色胺的 8-酰化类似物。
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