NiKem Research, via Zambeletti 25, 20021 Baranzate, Milan, Italy.
Molecules. 2010 Jan 6;15(1):178-97. doi: 10.3390/molecules15010178.
In the last few years click chemistry reactions, and in particular copper-catalyzed cycloadditions, have been used intensively for the preparation of new bioconjugate molecules and materials applicable to biomedical and pharmaceutical areas. This review will be focused on conjugates of the tripeptide Arg-Gly-Asp formed by means of click chemistry reactions. This sequence is a well known binding motif for specific transmembrane proteins and is involved in cellular adhesion to the extracellular matrix, allowing the selective recognition of the biomolecule or polymer in which it is incorporated.
在过去的几年中，点击化学反应，特别是铜催化的环加成反应，已被广泛用于制备新的生物缀合物分子和材料，适用于生物医学和制药领域。这篇综述将集中讨论通过点击化学反应形成的三肽 Arg-Gly-Asp 的缀合物。该序列是一种众所周知的跨膜蛋白结合基序，参与细胞与细胞外基质的黏附，允许对其包含的生物分子或聚合物进行选择性识别。
