CNR-Istituto di Scienze e Tecnologie Molecolari (ISTM), Milan, Italy.
Bioconjug Chem. 2009 Aug 19;20(8):1611-7. doi: 10.1021/bc900155j. Epub 2009 Jul 22.
The α(v)β(3) integrin is an adhesion molecule involved in physiological and pathological angiogenesis as well as in tumor invasion and metastasis, and therefore, there is a strong interest in developing novel agents interacting with this molecule. We report the synthesis and characterization of fluorescent α(v)β(3) integrin probes and their use to visualize integrin α(v)β(3) expression on human normal and cancer cells. The fluorescent probes we describe here may be of use for noninvasive imaging of α(V)β(3) integrin expression also in vivo.
α(v)β(3) 整联蛋白是一种参与生理和病理血管生成以及肿瘤侵袭和转移的黏附分子，因此，人们强烈关注开发与该分子相互作用的新型试剂。我们报告了荧光α(v)β(3)整联蛋白探针的合成和表征，并将其用于可视化人正常和癌细胞上整合素 α(v)β(3)的表达。我们在这里描述的荧光探针也可能有助于在体内非侵入性地成像 α(V)β(3)整联蛋白的表达。
