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大鼠垂体中肌酸激酶比活性对雌激素化合物和维生素D低钙血症类似物的反应。

The response of creatine kinase specific activity in rat pituitary to estrogenic compounds and vitamin d less-calcemic analogs.

作者信息

Somjen D, Mirsky N, Tamir S, Vaya J, Posner G H, Kaye A M

机构信息

Institute of Endocrinology, Metabolism and Hypertension, Sourasky Medical Center, Tel-Aviv 64239, Israel.

出版信息

Int J Cell Biol. 2009;2009:273651. doi: 10.1155/2009/273651. Epub 2009 Sep 10.

DOI:10.1155/2009/273651
PMID:20111624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2809427/
Abstract

We examined the response of rat female pituitary at different metabolic stages to treatments with estrogenic compounds and vitamin D analogs. Immature or ovariectomized (Ovx) female rats responded by increased creatine kinase specific activity (CK) to estradiol-17beta (E(2)), genistein (G), daidzein (D), biochainin A (BA), quecertin (Qu), carboxy- G (cG), carboxy- BA (cBA), and raloxifene (Ral). The response was inhibited when Ral was injected together with the estrogens. CK was increased when hormones were injected daily into Ovx rats for 4 different time periods. Pretreatment with the less-calcemic vitamin D analogs JK 1624 F(2)-2 (JKF) or QW 1624 F(2)-2 (QW) followed by estrogenic injection resulted in increased response and sensitivity to E(2) and loss of inhibition of E(2) by Ral. CK was also increased by feeding with E(2) or licorice or its components dose- and time- dependent in immature or Ovxrats. Diabetic female rats did not respond to increased doses of E(2). In conclusion, rat female pituitary is estrogens-responsive organ, suggesting to considerits response for HRT in postmenopausal women for both beneficial and hazardous aspects.

摘要

我们研究了处于不同代谢阶段的大鼠雌性垂体对雌激素化合物和维生素D类似物治疗的反应。未成熟或去卵巢（Ovx）雌性大鼠对雌二醇-17β（E₂）、染料木黄酮（G）、大豆苷元（D）、生物链菌素A（BA）、槲皮素（Qu）、羧基-G（cG）、羧基-BA（cBA）和雷洛昔芬（Ral）的反应是肌酸激酶比活性（CK）增加。当Ral与雌激素一起注射时，这种反应受到抑制。当在4个不同时间段每天向Ovx大鼠注射激素时，CK增加。用低钙血症的维生素D类似物JK 1624 F₂-2（JKF）或QW 1624 F₂-2（QW）预处理后再注射雌激素，会导致对E₂的反应和敏感性增加，并且Ral对E₂的抑制作用丧失。在未成熟或Ovx大鼠中，通过给予E₂、甘草或其成分，CK也会呈剂量和时间依赖性增加。糖尿病雌性大鼠对增加剂量的E₂无反应。总之，大鼠雌性垂体是雌激素反应性器官，这表明在考虑绝经后妇女激素替代疗法的利弊时应考虑其反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f64/2809427/18a9bfaaf595/IJCB2009-273651.0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f64/2809427/af47f9087b62/IJCB2009-273651.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f64/2809427/882890ce9dd1/IJCB2009-273651.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f64/2809427/5ab1f1dc8dfe/IJCB2009-273651.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f64/2809427/18a9bfaaf595/IJCB2009-273651.0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f64/2809427/af47f9087b62/IJCB2009-273651.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f64/2809427/61834acdafe2/IJCB2009-273651.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f64/2809427/14cfb2aa82c3/IJCB2009-273651.003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f64/2809427/43319d5e87d6/IJCB2009-273651.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f64/2809427/6d2a3c2cb770/IJCB2009-273651.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f64/2809427/8f5356a79232/IJCB2009-273651.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f64/2809427/882890ce9dd1/IJCB2009-273651.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f64/2809427/5ab1f1dc8dfe/IJCB2009-273651.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f64/2809427/18a9bfaaf595/IJCB2009-273651.0010.jpg

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