Laboratory of Plant Biotechnology, Biology Department, West University of Timişoara, Pestalozzi Str. 16, RO-300115, Romania.
Laboratory of Computational and Structural Physical Chemistry, Chemistry Department, West University of Timişoara, Pestalozzi Str. 16, RO-300115, Romania.
Int J Mol Sci. 2009 Aug 18;10(8):3616-3634. doi: 10.3390/ijms10083616.
The polysaccharide-containing extracellular fractions (EFs) of the edible mushroom Pleurotus ostreatus have immunomodulating effects. Being aware of these therapeutic effects of mushroom extracts, we have investigated the synergistic relations between these extracts and BIAVAC and BIAROMVAC vaccines. These vaccines target the stimulation of the immune system in commercial poultry, which are extremely vulnerable in the first days of their lives. By administrating EF with polysaccharides from P. ostreatus to unvaccinated broilers we have noticed slow stimulation of maternal antibodies against infectious bursal disease (IBD) starting from four weeks post hatching. For the broilers vaccinated with BIAVAC and BIAROMVAC vaccines a low to almost complete lack of IBD maternal antibodies has been recorded. By adding 5% and 15% EF in the water intake, as compared to the reaction of the immune system in the previous experiment, the level of IBD antibodies was increased. This has led us to believe that by using this combination of BIAVAC and BIAROMVAC vaccine and EF from P. ostreatus we can obtain good results in stimulating the production of IBD antibodies in the period of the chicken first days of life, which are critical to broilers' survival. This can be rationalized by the newly proposed reactivity biological activity (ReBiAc) principles by examining the parabolic relationship between EF administration and recorded biological activity.
含有多糖的可食性蘑菇糙皮侧耳的胞外成分（EFs）具有免疫调节作用。鉴于蘑菇提取物的这些治疗效果，我们研究了这些提取物与 BIAVAC 和 BIAROMVAC 疫苗之间的协同关系。这些疫苗的目标是刺激商业家禽的免疫系统，而家禽在生命的最初几天极其脆弱。通过给未接种疫苗的肉鸡施用含有多糖的 EF，我们注意到从孵化后四周开始，针对传染性法氏囊病（IBD）的母源抗体的刺激作用缓慢。对于接种了 BIAVAC 和 BIAROMVAC 疫苗的肉鸡，记录到 IBD 母源抗体的水平低至几乎完全缺乏。与之前实验中免疫系统的反应相比，通过在饮用水中添加 5%和 15%的 EF，IBD 抗体水平增加。这使我们相信，通过使用 BIAVAC 和 BIAROMVAC 疫苗与来自糙皮侧耳的 EF 的这种组合，我们可以在刺激鸡生命最初几天的 IBD 抗体产生方面取得良好的效果，这对肉鸡的生存至关重要。通过检查 EF 施用与记录的生物活性之间的抛物线关系，可以根据新提出的反应性生物活性（ReBiAc）原理来合理化这一点。
Zotero 插件
