University Medical Centre Groningen, Groningen, The Netherlands.
J Rehabil Med. 2010 Jan;42(1):56-9. doi: 10.2340/16501977-0481.
To test the hypothesis that cognitive functioning is associated with subjective quality of life of young adults with spina bifida and hydrocephalus (SBHC).
Cross-sectional multi-centre study in The Netherlands.
A total of 110 young adults with SBHC (16-25 years old, 63% female).
Cognitive domains measured were intelligence (Raven Standard Progressive Matrices), memory (Wechsler Memory Scale) and executive functioning (Wisconsin modified Card Sorting Test (WmCST), Trail Making Test A and B (TMT) and UNKA word production test). Subjective quality of life was measured with a visual analogue scale. Correlations and hierarchical regression analysis controlling for age, gender and functional independence were applied.
The TMT score was significantly associated (-0.25) with subjective quality of life. In the hierarchical regression analysis both the WmCST and TMT scores were significant determinants of subjective quality of life (Beta values 0.24 and -0.31 respectively). Intelligence, memory and word production were not related to subjective quality of life. All 5 cognitive variables together explained a significant additional 14.6% of the variance of subjective quality of life (total explained variance 19.9%).
Executive functioning was associated with subjective quality of life in young adults with spina bifida and hydrocephalus. This finding underlines the importance of examining cognitive functioning of persons with SBHC in addition to medical and functional status in medical care and outcome research.
检验认知功能与脊柱裂伴脑积水（SBHC）的年轻成年人主观生活质量相关的假设。
荷兰的一项横断面多中心研究。
共 110 名年轻的 SBHC 患者（16-25 岁，63%为女性）。
测量的认知域包括智力（瑞文标准渐进矩阵）、记忆（韦氏记忆量表）和执行功能（威斯康星卡片分类测试修订版（WmCST）、连线测试 A 和 B（TMT）和 UNKA 单词生成测试）。主观生活质量用视觉模拟量表进行测量。应用相关分析和分层回归分析，控制年龄、性别和功能独立性。
TMT 评分与主观生活质量显著相关（-0.25）。在分层回归分析中，WmCST 和 TMT 评分都是主观生活质量的显著决定因素（Beta 值分别为 0.24 和-0.31）。智力、记忆和单词生成与主观生活质量无关。所有 5 个认知变量共同解释了主观生活质量的 14.6%的显著额外方差（总解释方差为 19.9%）。
执行功能与脊柱裂伴脑积水的年轻成年人的主观生活质量相关。这一发现强调了在医疗和功能状态之外，检查 SBHC 患者认知功能在医疗保健和结果研究中的重要性。
