Park Shin Ae, Park Young Woo, Son Won Gyun, Kim Tae Hyun, Ahn Jae Sang, Ahn Jeong Taek, Kim Se Eun, Lee Inhyung, Seo Kangmoon
Department of Veterinary Surgery and Ophthalmology, Seoul National University, San 56-1, Sillim 9-dong, Gwanak-gu, Seoul 151-742, Republic of Korea.
Am J Vet Res. 2010 Feb;71(2):216-22. doi: 10.2460/ajvr.71.2.216.
To evaluate the intraoperative and postoperative analgesic effects of intracameral lidocaine hydrochloride injection in dogs undergoing phacoemulsification.
12 healthy Beagles with healthy eyes.
Dogs were randomly assigned to receive 1 of 2 intracameral injections: 2% lidocaine hydrochloride solution (0.3 mL) or an equivalent amount of balanced salt solution (BSS). All dogs were treated with acepromazine (0.05 mg/kg, i.v.) and cefazolin (30 mg/kg, i.v.), and tropicamide drops were topically applied to the eyes. Anesthesia was induced with propofol and maintained with isoflurane. The initial end-tidal isoflurane concentration was maintained at 1.2%. Heart rate, respiratory rate, arterial blood pressure, esophageal temperature, inspired and end-tidal isoflurane concentrations, and oxygen saturation were recorded every 5 minutes. The allocated agent was injected intracamerally after aspiration of the same volume of aqueous humor. Ten minutes after injection, phacoemulsification was performed. After surgery began, the isoflurane concentration was adjusted according to heart rate and mean arterial blood pressure. Pain scores were recorded before surgery and at 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 6, 8, 16, and 24 hours after extubation.
Isoflurane requirements were significantly higher in the BSS group than in the lidocaine group. Mean +/- SD time to administration of supplementary analgesia was significantly shorter in the BSS group (1.4 +/- 1.2 hours) than in the lidocaine group (4.9 +/- 1.2 hours).
Intracameral lidocaine injection had significant analgesic effects in dogs undergoing cataract surgery. Results of this study suggest the value of intracameral lidocaine injection as an analgesic for intraocular surgery in dogs.
评估在接受超声乳化白内障吸除术的犬中前房内注射盐酸利多卡因的术中和术后镇痛效果。
12只双眼健康的比格犬。
将犬随机分为两组接受两种前房内注射之一：2%盐酸利多卡因溶液（0.3毫升）或等量的平衡盐溶液（BSS）。所有犬均接受乙酰丙嗪（0.05毫克/千克，静脉注射）和头孢唑林（30毫克/千克，静脉注射）治疗，眼部局部应用托吡卡胺滴眼液。用丙泊酚诱导麻醉并用异氟烷维持。初始呼气末异氟烷浓度维持在1.2%。每5分钟记录心率、呼吸频率、动脉血压、食管温度、吸入和呼气末异氟烷浓度以及氧饱和度。在吸出等量房水后将分配的药物前房内注射。注射后10分钟，进行超声乳化白内障吸除术。手术开始后，根据心率和平均动脉血压调整异氟烷浓度。在拔管前和拔管后0.5、1、1.5、2、2.5、3、3.5、4、6、8、16和24小时记录疼痛评分。
BSS组的异氟烷需求量显著高于利多卡因组。BSS组（1.4±1.2小时）给予补充镇痛的平均±标准差时间显著短于利多卡因组（4.9±1.2小时）。
前房内注射利多卡因对接受白内障手术的犬有显著镇痛效果。本研究结果表明前房内注射利多卡因作为犬眼内手术镇痛剂的价值。
