Nemes Attila, Ungi Imre, Csanády Miklós, Forster Tamás
2nd Department of Medicine and Cardiology Center, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, H-6720 Szeged, Hungary.
Echocardiography. 2010 Mar;27(3):311-6. doi: 10.1111/j.1540-8175.2009.01006.x. Epub 2010 Jan 22.
Deteriorations in coronary flow velocity reserve (CFR) and aortic distensibility have been demonstrated in coronary artery disease. The objective of the present study was a simultaneous echocardiographic evaluation of the CFR and aortic distensibility indices before and after successful percutaneous coronary interventions (PCI) in patients with left anterior descending coronary artery (LAD) disease.
The study population, comprising 12 patients (4 women and 8 men) with significant proximal LAD stenosis, were compared with matched controls. Transesophageal echocardiography (TEE) was carried out to evaluate the CFR and aortic distensibility indices (the aortic elastic modulus E(p) and Young's circumferential static elastic modulus E(s)) before and after PCI to the LAD. The subjects underwent TEE on average 8 +/- 11 days before PCI and 25 +/- 6 weeks after PCI.
An improvement in CFR was demonstrated in patients with LAD stenosis after successful PCI (1.71 +/- 0.36 vs. 2.08 +/- 0.28, P < 0.05), which paralleled the decreases in E(p) (936 +/- 544 mmHg vs. 567 +/- 184 mmHg, P < 0.05) and E(s) (10,207 +/- 6,295 mmHg vs. 5,831 +/- 2,010 mmHg, P < 0.05) during the follow-up.
The aortic distensibility improves in parallel with the increase in CFR in patients with LAD stenosis after successful PCI.
冠状动脉疾病患者已证实存在冠状动脉血流储备（CFR）降低和主动脉扩张性减退。本研究的目的是对左前降支冠状动脉（LAD）疾病患者成功进行经皮冠状动脉介入治疗（PCI）前后的CFR和主动脉扩张性指标进行同步超声心动图评估。
将12例（4例女性和8例男性）近端LAD严重狭窄患者的研究人群与匹配的对照组进行比较。在对LAD进行PCI前后，采用经食管超声心动图（TEE）评估CFR和主动脉扩张性指标（主动脉弹性模量E(p)和周向杨氏静态弹性模量E(s)）。受试者在PCI前平均8±11天和PCI后25±6周接受TEE检查。
成功进行PCI后，LAD狭窄患者的CFR有所改善（1.71±0.36对2.08±0.28，P<0.05），这与随访期间E(p)（936±544 mmHg对567±184 mmHg，P<0.05）和E(s)（10,207±6,295 mmHg对5,831±2,010 mmHg，P<0.05）的降低相一致。
成功进行PCI后，LAD狭窄患者的主动脉扩张性与CFR的增加同步改善。
