Mitznegg P, Estler C J, Loew F W, van Seil J
Acta Hepatogastroenterol (Stuttg). 1977 Oct;24(5):372-6.
Studies on the cyclic AMP content of isolated rat gastric mucosa have been conducted with sodium salicylate and lysine-acetylsalicylate singly and combined with gastric secretagogues and their antagonists. Both salicylates at a concentration of 1.66 X 10(-2) M increased the amount of cyclic AMP. The increase of gastric mucosal cyclic AMP produced by sodium salicylate was diminished by prostaglandin E1 (10(-5) M), atropine (10(-6) M) and the H2-antihistamine metiamide (2 X 10(-4) M). Theophylline 3 X 10(-3) M), histamine (10(-3) M) and pentagastrin (10(-6) M) did not enhance the cyclic-AMP-response to salicylate or lysine-acetyl-salicylate.
已分别使用水杨酸钠和赖氨酸 - 乙酰水杨酸酯，并将它们与胃分泌刺激剂及其拮抗剂联合使用，对分离的大鼠胃黏膜中的环磷酸腺苷（cAMP）含量进行了研究。两种水杨酸酯在浓度为1.66×10⁻² M时均增加了环磷酸腺苷的量。前列腺素E1（10⁻⁵ M）、阿托品（10⁻⁶ M）和H2 - 抗组胺药甲硫米特（2×10⁻⁴ M）可减少水杨酸钠引起的胃黏膜环磷酸腺苷的增加。3×10⁻³ M的茶碱、10⁻³ M的组胺和10⁻⁶ M的五肽胃泌素并未增强对水杨酸酯或赖氨酸 - 乙酰水杨酸酯的环磷酸腺苷反应。
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