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Exp Ther Med. 2015 Jun;9(6):2394-2400. doi: 10.3892/etm.2015.2392. Epub 2015 Mar 27.

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Clinical significance of the humoral immune response to modified LDL.修饰性 LDL 抗体的体液免疫应答的临床意义。
Clin Immunol. 2010 Jan;134(1):55-65. doi: 10.1016/j.clim.2009.04.001. Epub 2009 May 8.
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Relationship between oxidized LDL antibodies and different stages of esophageal carcinoma.氧化型低密度脂蛋白抗体与食管癌不同阶段之间的关系。
Arch Med Res. 2008 Nov;39(8):760-7. doi: 10.1016/j.arcmed.2008.08.002.
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Distribution of IgM and IgG antibodies to oxidized LDL in immune complexes isolated from patients with type 1 diabetes and its relationship with nephropathy.1型糖尿病患者分离出的免疫复合物中抗氧化型低密度脂蛋白IgM和IgG抗体的分布及其与肾病的关系。
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Adiponectin in relation to childhood myeloblastic leukaemia.脂联素与儿童髓细胞白血病的关系
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Immunoglobulin M type of autoantibodies to oxidized low-density lipoprotein has an inverse relation to carotid artery atherosclerosis.氧化型低密度脂蛋白免疫球蛋白M型自身抗体与颈动脉粥样硬化呈负相关。
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4-Hydroxy-2-nonenal: a product and mediator of oxidative stress.4-羟基-2-壬烯醛：氧化应激的产物与介质
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Autoantibodies against oxidized low-density lipoprotein and cardiolipin in patients with coronary heart disease.冠心病患者中抗氧化型低密度脂蛋白和心磷脂自身抗体
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[Epidemiological remarks on low serum cholesterol level and cancer risk of all sites].[关于低血清胆固醇水平与所有部位癌症风险的流行病学评论]
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氧化低密度脂蛋白 IgG（oxLDL-lgG）和氧化低密度脂蛋白 IgM 自身抗体与成人急性髓细胞性白血病的关系。

The association between serum levels of oxLDL-lgG and oxLDL-lgM autoantibody with adult acute myeloblastic leukaemia.

机构信息

Tumor Center of Qilu Hospital, Shandong University, Jinan, PR China.

出版信息

Lipids Health Dis. 2010 Jan 31;9:11. doi: 10.1186/1476-511X-9-11.

DOI:10.1186/1476-511X-9-11
PMID:20113525
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2834680/
Abstract

AIM

To evaluate the relationship between serum antibodies against ox-LDL levels and adult acute myeloblastic leukemia (AML).

METHODS

Forty three patients with AML and 52 normal controls were enrolled in this study in the Department of Hematology, Tumor Center of Qilu Hospital of Shandong University from Feb. 2008 to Mar.2009. Serum lgG and lgM antibodies versus the oxLDL levels were evaluated by ELISA method. Data was analyzed by covariance and binary Logistic regression.

RESULTS

Serum mean levels of oxLDL-lgG in patients (38.92 +/- 21.1259 ug/ml) were significantly lower than in control subjects (78.88 +/- 9.3705 ug/ml); Meanwhile, Serum mean levels of oxLDL-lgM in patients (20.53 +/- 10.2990 IU/L) were significantly higher than in control subjects (10.29 +/- 10.5771 IU/L). Binary logistic regression showed the odds ratios of association of oxLD-lgG and oxLD-lgM with adult AML were 0.72(95%CI: 0.55-0.94) and 1.11(95%CI: 1.01-1.21) respectively after adjusted for potential confounders.

CONCLUSION

In the preliminary investigation we found a descensive oxLDL- lgG and an elevated oxLDL-lgM serum levels for the adult AML. Future studies need to confirm the hypothesis whether they related to the development and progression of adult AML.

摘要

目的

评估血清抗 ox-LDL 抗体水平与成人急性髓系白血病（AML）的关系。

方法

2008 年 2 月至 2009 年 3 月，在山东大学齐鲁医院血液肿瘤中心，纳入 43 例 AML 患者和 52 名正常对照者。采用 ELISA 法检测血清 IgG 和 IgM 抗体与 oxLDL 水平。数据采用协方差和二项 Logistic 回归进行分析。

结果

患者 oxLDL-lgG 的血清平均水平（38.92 +/- 21.1259 ug/ml）明显低于对照组（78.88 +/- 9.3705 ug/ml）；同时，患者 oxLDL-lgM 的血清平均水平（20.53 +/- 10.2990 IU/L）明显高于对照组（10.29 +/- 10.5771 IU/L）。二元逻辑回归显示，调整潜在混杂因素后，oxLD-lgG 和 oxLD-lgM 与成人 AML 的关联的优势比分别为 0.72（95%CI：0.55-0.94）和 1.11（95%CI：1.01-1.21）。

结论

在初步研究中，我们发现成人 AML 患者的 oxLDL-lgG 降低，oxLDL-lgM 血清水平升高。未来的研究需要证实它们是否与成人 AML 的发生和发展有关。